E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
1_MELPA 6_ VGEHV 11_ FAVES 16_ IEKKR 21_ IRKGR 26_ VEYLV 31_ KWRGW 36_ SPKYN 41_ TWEPE 46_ ENILD 51_ PRLLI 56_ AFQNR 61_ ERQEQ 66_ LMGYR 71_ KRGPK 76_ PKPLV 81_ VQVPT 86_ FARRS 91_ NVLTG 96_ LQDSS 101_ TDNRA 106_ KLDLG 111_ AQGKG 116_ QGHQY 121_ ELNSK 126_ KHHQY 131_ QPHSK 136_ ERAGK 141_ PPPPG 146_ KSGKY 151_ YYQLN 156_ SKKHH 161_ PYQPD 166_ PKMYD 171_ LQYQG 176_ GHKEA 181_ PSPTC 186_ PDLGA 191_ KSHPP 196_ DKWAQ 201_ GAGAK 206_ GYLGA 211_ VKPLA 216_ GAAGA 221_ PGKGS 226_ EKGPP 231_ NGMMP 236_ APKEA 241_ VTGNG 246_ IGGKM 251_ KIVKN 256_ KNKNG 261_ RIVIV 266_ MSKYM 271_ ENGMQ 276_ AVKIK 281_ SGEVA 286_ EGEAR 291_ SPSHK 296_ KRAAD 301_ ERHPP 306_ ADRTF 311_ KKAAG 316_ AEEKK 321_ VEAPP 326_ KRREE 331_ EVSGV 336_ SDPQP 341_ QDAGS 346_ RKLSP 351_ TKEAF 356_ GEQPL 361_ QLTTK 366_ PDLLA 371_ WDPAR 376_ NTHPP 381_ SHHPH 386_ PHPHH 391_ HHHHH 396_ HHHHH 401_ AVGLN 406_ LSHVR 411_ KRCLS 416_ ETHGE 421_ REPCK 426_ KRLTA 431_ RSIST 436_ PTCLG 441_ GSPAA 446_ ERPAD 451_ LPPAA 456_ ALPQP 461_ EVILL 466_ DSDLD 471_ EPIDL 476_ RCVKT 481_ RSEAG 486_ EPPSS 491_ LQVKP 496_ ETPAS 501_ AAVAV 506_ AAAAA 511_ PTTTA 516_ EKPPA 521_ EAQDE 526_ PAESL 531_ SEFKP 536_ FFGNI 541_ IITDV 546_ TANCL 551_TVTFK
1: E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850)
2: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity)