Guided entry of tail-anchored proteins factor 1 (Congenital heart disease 5 protein) (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein)
1_MSSAA 6_ ADHWA 11_ WLLVL 16_ SFVFG 21_ CNVLR 26_ ILLPS 31_ FSSFM 36_ SRVLQ 41_ KDAEQ 46_ ESQMR 51_ AEIQD 56_ MKQEL 61_ STVNM 66_ MDEFA 71_ RYARL 76_ ERKIN 81_ KMTDK 86_ LKTHV 91_ KARTA 96_ QLAKI 101_ KWVIS 106_ VAFYV 111_ LQAAL 116_ MISLI 121_ WKYYS 126_ VPVAV 131_ VPSKW 136_ ITPLD 141_ RLVAF 146_ PTRVA 151_ GGVGI 156_ TCWIL 161_ VCNKV 166_VAIVL
1: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542)