Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
1_MSDSE 6_ DSNFS 11_ EEEDS 16_ ERSSD 21_ GEEAE 26_ VDEER 31_ RSAAG 36_ SEKEE 41_ EPEDE 46_ EEEEE 51_ EEEYD 56_ EEEEE 61_ EDDDR 66_ PPKKP 71_ RHGGF 76_ ILDEA 81_ DVDDE 86_ YEDED 91_ QWEDG 96_ AEDIL 101_ EKEEI 106_ EASNI 111_ DNVVL 116_ DEDRS 121_ GARRL 126_ QNLWR 131_ DQREE 136_ ELGEY 141_ YMKKY 146_ AKSSV 151_ GETVY 156_ GGSDE 161_ LSDDI 166_ TQQQL 171_ LPGVK 176_ DPNLW 181_ TVKCK 186_ IGEER 191_ ATAIS 196_ LMRKF 201_ IAYQF 206_ TDTPL 211_ QIKSV 216_ VAPEH 221_ VKGYI 226_ YVEAY 231_ KQTHV 236_ KQAIE 241_ GVGNL 246_ RLGYW 251_ NQQMV 256_ PIKEM 261_ TDVLK 266_ VVKEV 271_ ANLKP 276_ KSWVR 281_ LKRGI 286_ YKDDI 291_ AQVDY 296_ VEPSQ 301_ NTISL 306_ KMIPR 311_ IDYDR 316_ IKARM 321_ SLKDW 326_ FAKRK 331_ KFKRP 336_ PQRLF 341_ DAEKI 346_ RSLGG 351_ DVASD 356_ GDFLI 361_ FEGNR 366_ YSRKG 371_ FLFKS 376_ FAMSA 381_ VITEG 386_ VKPTL 391_ SELEK 396_ FEDQP 401_ EGIDL 406_ EVVTE 411_ STGKE 416_ REHNF 421_ QPGDN 426_ VEVCE 431_ GELIN 436_ LQGKI 441_ LSVDG 446_ NKITI 451_ MPKHE 456_ DLKDM 461_ LEFPA 466_ QELRK 471_ YFKMG 476_ DHVKV 481_ IAGRF 486_ EGDTG 491_ LIVRV 496_ EENFV 501_ ILFSD 506_ LTMHE 511_ LKVLP 516_ RDLQL 521_ CSETA 526_ SGVDV 531_ GGQHE 536_ WGELV 541_ QLDPQ 546_ TVGVI 551_ VRLER 556_ ETFQV 561_ LNMYG 566_ KVVTV 571_ RHQAV 576_ TRKKD 581_ NRFAV 586_ ALDSE 591_ QNNIH 596_ VKDIV 601_ KVIDG 606_ PHSGR 611_ EGEIR 616_ HLFRS 621_ FAFLH 626_ CKKLV 631_ ENGGM 636_ FVCKT 641_ RHLVL 646_ AGGSK 651_ PRDVT 656_ NFTVG 661_ GFAPM 666_ SPRIS 671_ SPMHP 676_ SAGGQ 681_ RGGFG 686_ SPGGG 691_ SGGMS 696_ RGRGR 701_ RDNEL 706_ IGQTV 711_ RISQG 716_ PYKGY 721_ IGVVK 726_ DATES 731_ TARVE 736_ LHSTC 741_ QTISV 746_ DRQRL 751_ TTVGS 756_ RRPGG 761_ MTSTY 766_ GRTPM 771_ YGSQT 776_ PMYGS 781_ GSRTP 786_ MYGSQ 791_ TPLQD 796_ GSRTP 801_ HYGSQ 806_ TPLHD 811_ GSRTP 816_ AQSGA 821_ WDPNN 826_ PNTPS 831_ RAEEE 836_ YEYAF 841_ DDEPT 846_ PSPQA 851_ YGGTP 856_ NPQTP 861_ GYPDP 866_ SSPQV 871_ NPQYN 876_ PQTPG 881_ TPAMY 886_ NTDQF 891_ SPYAA 896_ PSPQG 901_ SYQPS 906_ PSPQS 911_ YHQVA 916_ PSPAG 921_ YQNTH 926_ SPASY 931_ HPTPS 936_ PMAYQ 941_ ASPSP 946_ SPVGY 951_ SPMTP 956_ GAPSP 961_ GGYNP 966_ HTPGS 971_ GIEQN 976_ SSDWV 981_ TTDIQ 986_ VKVRD 991_ TYLDT 996_ QVVGQ 1001_ TGVIR 1006_ SVTGG 1011_ MCSVY 1016_ LKDSE 1021_ KVVSI 1026_ SSEHL 1031_ EPITP 1036_ TKNNK 1041_ VKVIL 1046_ GEDRE 1051_ ATGVL 1056_ LSIDG 1061_ EDGIV 1066_ RMDLD 1071_ EQLKI 1076_ LNLRF 1081_LGKLL
1: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750)