12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor (12-(S)-HETE receptor) (12-HETER) (G-protein coupled receptor 31) (GPR31/12-HETER)
1_MPFPN 6_ CSAPS 11_ TVVAT 16_ AVGVL 21_ LGLEC 26_ GLGLL 31_ GNAVA 36_ LWTFL 41_ FRVRV 46_ WKPYA 51_ VYLLN 56_ LALAD 61_ LLLAA 66_ CLPFL 71_ AAFYL 76_ SLQAW 81_ HLGRV 86_ GCWAL 91_ HFLLD 96_ LSRSV 101_ GMAFL 106_ AAVAL 111_ DRYLR 116_ VVHPR 121_ LKVNL 126_ LSPQA 131_ ALGVS 136_ GLVWL 141_ LMVAL 146_ TCPGL 151_ LISEA 156_ AQNST 161_ RCHSF 166_ YSRAD 171_ GSFSI 176_ IWQEA 181_ LSCLQ 186_ FVLPF 191_ GLIVF 196_ CNAGI 201_ IRALQ 206_ KRLRE 211_ PEKQP 216_ KLQRA 221_ QALVT 226_ LVVVL 231_ FALCF 236_ LPCFL 241_ ARVLM 246_ HIFQN 251_ LGSCR 256_ ALCAV 261_ AHTSD 266_ VTGSL 271_ TYLHS 276_ VLNPV 281_ VYCFS 286_ SPTFR 291_ SSYRR 296_ VFHTL 301_ RGKGQ 306_ AAEPP 311_DFNPR
1: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed:21712392, PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed:26965684, PubMed:28619714, PubMed:29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed:21712392, PubMed:29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed:28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475)
2: Proton-sensing G protein-coupled receptor