Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)
1_MDRMA 6_ SSMKQ 11_ VPNPL 16_ PKVLS 21_ RRGVG 26_ AGLEA 31_ AERES 36_ FERTQ 41_ TVSIN 46_ KAINT 51_ QEVAV 56_ KEKHA 61_ RTCIL 66_ GTHHE 71_ KGAQT 76_ FWSVV 81_ NRLPL 86_ SSNAV 91_ LCWKF 96_ CHVFH 101_ KLLRD 106_ GHPNV 111_ LKDSL 116_ RYRNE 121_ LSDMS 126_ RMWGH 131_ LSEGY 136_ GQLCS 141_ IYLKL 146_ LRTKM 151_ EYHTK 156_ NPRFP 161_ GNLQM 166_ SDRQL 171_ DEAGE 176_ SDVNN 181_ FFQLT 186_ VEMFD 191_ YLECE 196_ LNLFQ 201_ TVFNS 206_ LDMSR 211_ SVSVT 216_ AAGQC 221_ RLAPL 226_ IQVIL 231_ DCSHL 236_ YDYTV 241_ KLLFK 246_ LHSCL 251_ PADTL 256_ QGHRD 261_ RFMEQ 266_ FTKLK 271_ DLFYR 276_ SSNLQ 281_ YFKRL 286_ IQIPQ 291_ LPENP 296_ PNFLR 301_ ASALS 306_ EHISP 311_ VVVIP 316_ AEASS 321_ PDSEP 326_ VLEKD 331_ DLMDM 336_ DASQQ 341_ NLFDN 346_ KFDDI 351_ FGSSF 356_ SSDPF 361_ NFNSQ 366_ NGVNK 371_ DEKDH 376_ LIERL 381_ YREIS 386_ GLKAQ 391_ LENMK 396_ TESQR 401_ VVLQL 406_ KGHVS 411_ ELEAD 416_ LAEQQ 421_ HLRQQ 426_ AADDC 431_ EFLRA 436_ ELDEL 441_ RRQRE 446_ DTEKA 451_ QRSLS 456_ EIERK 461_ AQANE 466_ QRYSK 471_ LKEKY 476_ SELVQ 481_ NHADL 486_ LRKNA 491_ EVTKQ 496_ VSMAR 501_ QAQVD 506_ LEREK 511_ KELED 516_ SLERI 521_ SDQGQ 526_ RKTQE 531_ QLEVL 536_ ESLKQ 541_ ELATS 546_ QRELQ 551_ VLQGS 556_ LETSA 561_ QSEAN 566_ WAAEF 571_ AELEK 576_ ERDSL 581_ VSGAA 586_ HREEE 591_ LSALR 596_ KELQD 601_ TQLKL 606_ ASTEE 611_ SMCQL 616_ AKDQR 621_ KMLLV 626_ GSRKA 631_ AEQVI 636_ QDALN 641_ QLEEP 646_ PLISC 651_ AGSAD 656_ HLLST 661_ VTSIS 666_ SCIEQ 671_ LEKSW 676_ SQYLA 681_ CPEDI 686_ SGLLH 691_ SITLL 696_ AHLTS 701_ DAIAH 706_ GATTC 711_ LRAPP 716_ EPADS 721_ LTEAC 726_ KQYGR 731_ ETLAY 736_ LASLE 741_ EEGSL 746_ ENADS 751_ TAMRN 756_ CLSKI 761_ KAIGE 766_ ELLPR 771_ GLDIK 776_ QEELG 781_ DLVDK 786_ EMAAT 791_ SAAIE 796_ TATAR 801_ IEEML 806_ SKSRA 811_ GDTGV 816_ KLEVN 821_ ERILG 826_ CCTSL 831_ MQAIQ 836_ VLIVA 841_ SKDLQ 846_ REIVE 851_ SGRGT 856_ ASPKE 861_ FYAKN 866_ SRWTE 871_ GLISA 876_ SKAVG 881_ WGATV 886_ MVDAA 891_ DLVVQ 896_ GRGKF 901_ EELMV 906_ CSHEI 911_ AASTA 916_ QLVAA 921_ SKVKA 926_ DKDSP 931_ NLAQL 936_ QQASR 941_ GVNQA 946_ TAGVV 951_ ASTIS 956_ GKSQI 961_ EETDN 966_ MDFSS 971_ MTLTQ 976_ IKRQE 981_ MDSQV 986_ RVLEL 991_ ENELQ 996_ KERQK 1001_ LGELR 1006_ KKHYE 1011_ LAGVA 1016_ EGWEE 1021_ GTEAS 1026_ PPTLQ 1031_EVVTE
1: Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454)