Chloride intracellular channel protein 1 (Chloride channel ABP) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC)
1_MAEEQ 6_ PQVEL 11_ FVKAG 16_ SDGAK 21_ IGNCP 26_ FSQRL 31_ FMVLW 36_ LKGVT 41_ FNVTT 46_ VDTKR 51_ RTETV 56_ QKLCP 61_ GGQLP 66_ FLLYG 71_ TEVHT 76_ DTNKI 81_ EEFLE 86_ AVLCP 91_ PRYPK 96_ LAALN 101_ PESNT 106_ AGLDI 111_ FAKFS 116_ AYIKN 121_ SNPAL 126_ NDNLE 131_ KGLLK 136_ ALKVL 141_ DNYLT 146_ SPLPE 151_ EVDET 156_ SAEDE 161_ GVSQR 166_ KFLDG 171_ NELTL 176_ ADCNL 181_ LPKLH 186_ IVQVV 191_ CKKYR 196_ GFTIP 201_ EAFRG 206_ VHRYL 211_ SNAYA 216_ REEFA 221_ STCPD 226_ DEEIE 231_ LAYEQ 236_VAKAL
1: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle