Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin)
1_MNNLL 6_ CCALV 11_ FLDIS 16_ IKWTT 21_ QETFP 26_ PKYLH 31_ YDEET 36_ SHQLL 41_ CDKCP 46_ PGTYL 51_ KQHCT 56_ AKWKT 61_ VCAPC 66_ PDHYY 71_ TDSWH 76_ TSDEC 81_ LYCSP 86_ VCKEL 91_ QYVKQ 96_ ECNRT 101_ HNRVC 106_ ECKEG 111_ RYLEI 116_ EFCLK 121_ HRSCP 126_ PGFGV 131_ VQAGT 136_ PERNT 141_ VCKRC 146_ PDGFF 151_ SNETS 156_ SKAPC 161_ RKHTN 166_ CSVFG 171_ LLLTQ 176_ KGNAT 181_ HDNIC 186_ SGNSE 191_ STQKC 196_ GIDVT 201_ LCEEA 206_ FFRFA 211_ VPTKF 216_ TPNWL 221_ SVLVD 226_ NLPGT 231_ KVNAE 236_ SVERI 241_ KRQHS 246_ SQEQT 251_ FQLLK 256_ LWKHQ 261_ NKDQD 266_ IVKKI 271_ IQDID 276_ LCENS 281_ VQRHI 286_ GHANL 291_ TFEQL 296_ RSLME 301_ SLPGK 306_ KVGAE 311_ DIEKT 316_ IKACK 321_ PSDQI 326_ LKLLS 331_ LWRIK 336_ NGDQD 341_ TLKGL 346_ MHALK 351_ HSKTY 356_ HFPKT 361_ VTQSL 366_ KKTIR 371_ FLHSF 376_ TMYKL 381_ YQKLF 386_ LEMIG 391_ NQVQS 396_VKISC
1: Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis