Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)
1_MATPA 6_ VPVSA 11_ PPATP 16_ TPVPA 21_ AAPAS 26_ VPAPT 31_ PAPAA 36_ APVPA 41_ AAPAS 46_ SSDPA 51_ AAAAA 56_ TAAPG 61_ QTPAS 66_ AQAPA 71_ QTPAP 76_ ALPGP 81_ ALPGP 86_ FPGGR 91_ VVRLH 96_ PVILA 101_ SIVDS 106_ YERRN 111_ EGAAR 116_ VIGTL 121_ LGTVD 126_ KHSVE 131_ VTNCF 136_ SVPHN 141_ ESEDE 146_ VAVDM 151_ EFAKN 156_ MYELH 161_ KKVSP 166_ NELIL 171_ GWYAT 176_ GHDIT 181_ EHSVL 186_ IHEYY 191_ SREAP 196_ NPIHL 201_ TVDTS 206_ LQNGR 211_ MSIKA 216_ YVSTL 221_ MGVPG 226_ RTMGV 231_ MFTPL 236_ TVKYA 241_ YYDTE 246_ RIGVD 251_ LIMKT 256_ CFSPN 261_ RVIGL 266_ SSDLQ 271_ QVGGA 276_ SARIQ 281_ DALST 286_ VLQYA 291_ EDVLS 296_ GKVSA 301_ DNTVG 306_ RFLMS 311_ LVNQV 316_ PKIVP 321_ DDFET 326_ MLNSN 331_ INDLL 336_ MVTYL 341_ ANLTQ 346_ SQIAL 351_NEKLV
1: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)
2: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling