NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
1_MASAS 6_ SSRAG 11_ VALPF 16_ EKSQL 21_ TLKVV 26_ SAKPK 31_ VHNRQ 36_ PRINS 41_ YVEVA 46_ VDGLP 51_ SETKK 56_ TGKRI 61_ GSSEL 66_ LWNEI 71_ IILNV 76_ TAQSH 81_ LDLKV 86_ WSCHT 91_ LRNEL 96_ LGTAS 101_ VNLSN 106_ VLKNN 111_ GGKME 116_ NMQLT 121_ LNLQT 126_ ENKGS 131_ VVSGG 136_ ELTIF 141_ LDGPT 146_ VDLGN 151_ VPNGS 156_ ALTDG 161_ SQLPS 166_ RDSSG 171_ TAVAP 176_ ENRHQ 181_ PPSTN 186_ CFGGR 191_ SRTHR 196_ HSGAS 201_ ARTTP 206_ ATGEQ 211_ SPGAR 216_ SRHRQ 221_ PVKNS 226_ GHSGL 231_ ANGTV 236_ NDEPT 241_ TATDP 246_ EEPSV 251_ VGVTS 256_ PPAAP 261_ LSVTP 266_ NPNTT 271_ SLPAP 276_ ATPAE 281_ GEEPS 286_ TSGTQ 291_ QLPAA 296_ AQAPD 301_ ALPAG 306_ WEQRE 311_ LPNGR 316_ VYYVD 321_ HNTKT 326_ TTWER 331_ PLPPG 336_ WEKRT 341_ DPRGR 346_ FYYVD 351_ HNTRT 356_ TTWQR 361_ PTAEY 366_ VRNYE 371_ QWQSQ 376_ RNQLQ 381_ GAMQH 386_ FSQRF 391_ LYQSS 396_ SASTD 401_ HDPLG 406_ PLPPG 411_ WEKRQ 416_ DNGRV 421_ YYVNH 426_ NTRTT 431_ QWEDP 436_ RTQGM 441_ IQEPA 446_ LPPGW 451_ EMKYT 456_ SEGVR 461_ YFVDH 466_ NTRTT 471_ TFKDP 476_ RPGFE 481_ SGTKQ 486_ GSPGA 491_ YDRSF 496_ RWKYH 501_ QFRFL 506_ CHSNA 511_ LPSHV 516_ KISVS 521_ RQTLF 526_ EDSFQ 531_ QIMNM 536_ KPYDL 541_ RRRLY 546_ IIMRG 551_ EEGLD 556_ YGGIA 561_ REWFF 566_ LLSHE 571_ VLNPM 576_ YCLFE 581_ YAGKN 586_ NYCLQ 591_ INPAS 596_ SINPD 601_ HLTYF 606_ RFIGR 611_ FIAMA 616_ LYHGK 621_ FIDTG 626_ FTLPF 631_ YKRML 636_ NKRPT 641_ LKDLE 646_ SIDPE 651_ FYNSI 656_ VWIKE 661_ NNLEE 666_ CGLEL 671_ YFIQD 676_ MEILG 681_ KVTTH 686_ ELKEG 691_ GESIR 696_ VTEEN 701_ KEEYI 706_ MLLTD 711_ WRFTR 716_ GVEEQ 721_ TKAFL 726_ DGFNE 731_ VAPLE 736_ WLRYF 741_ DEKEL 746_ ELMLC 751_ GMQEI 756_ DMSDW 761_ QKSTI 766_ YRHYT 771_ KNSKQ 776_ IQWFW 781_ QVVKE 786_ MDNEK 791_ RIRLL 796_ QFVTG 801_ TCRLP 806_ VGGFA 811_ ELIGS 816_ NGPQK 821_ FCIDK 826_ VGKET 831_ WLPRS 836_ HTCFN 841_ RLDLP 846_ PYKSY 851_ EQLRE 856_ KLLYA 861_IEETE
1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation