Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
1_MPPGV 6_ DCPME 11_ FWTKE 16_ ENQSV 21_ VVDFL 26_ LPTGV 31_ YLNFP 36_ VSRNA 41_ NLSTI 46_ KQLLW 51_ HRAQY 56_ EPLFH 61_ MLSGP 66_ EAYVF 71_ TCINQ 76_ TAEQQ 81_ ELEDE 86_ QRRLC 91_ DVQPF 96_ LPVLR 101_ LVARE 106_ GDRVK 111_ KLINS 116_ QISLL 121_ IGKGL 126_ HEFDS 131_ LCDPE 136_ VNDFR 141_ AKMCQ 146_ FCEEA 151_ AARRQ 156_ QLGWE 161_ AWLQY 166_ SFPLQ 171_ LEPSA 176_ QTWGP 181_ GTLRL 186_ PNRAL 191_ LVNVK 196_ FEGSE 201_ ESFTF 206_ QVSTK 211_ DVPLA 216_ LMACA 221_ LRKKA 226_ TVFRQ 231_ PLVEQ 236_ PEDYT 241_ LQVNG 246_ RHEYL 251_ YGSYP 256_ LCQFQ 261_ YICSC 266_ LHSGL 271_ TPHLT 276_ MVHSS 281_ SILAM 286_ RDEQS 291_ NPAPQ 296_ VQKPR 301_ AKPPP 306_ IPAKK 311_ PSSVS 316_ LWSLE 321_ QPFRI 326_ ELIQG 331_ SKVNA 336_ DERMK 341_ LVVQA 346_ GLFHG 351_ NEMLC 356_ KTVSS 361_ SEVSV 366_ CSEPV 371_ WKQRL 376_ EFDIN 381_ ICDLP 386_ RMARL 391_ CFALY 396_ AVIEK 401_ AKKAR 406_ STKKK 411_ SKKAD 416_ CPIAW 421_ ANLML 426_ FDYKD 431_ QLKTG 436_ ERCLY 441_ MWPSV 446_ PDEKG 451_ ELLNP 456_ TGTVR 461_ SNPNT 466_ DSAAA 471_ LLICL 476_ PEVAP 481_ HPVYY 486_ PALEK 491_ ILELG 496_ RHSEC 501_ VHVTE 506_ EEQLQ 511_ LREIL 516_ ERRGS 521_ GELYE 526_ HEKDL 531_ VWKLR 536_ HEVQE 541_ HFPEA 546_ LARLL 551_ LVTKW 556_ NKHED 561_ VAQML 566_ YLLCS 571_ WPELP 576_ VLSAL 581_ ELLDF 586_ SFPDC 591_ HVGSF 596_ AIKSL 601_ RKLTD 606_ DELFQ 611_ YLLQL 616_ VQVLK 621_ YESYL 626_ DCELT 631_ KFLLD 636_ RALAN 641_ RKIGH 646_ FLFWH 651_ LRSEM 656_ HVPSV 661_ ALRFG 666_ LILEA 671_ YCRGS 676_ THHMK 681_ VLMKQ 686_ GEALS 691_ KLKAL 696_ NDFVK 701_ LSSQK 706_ TPKPQ 711_ TKELM 716_ HLCMR 721_ QEAYL 726_ EALSH 731_ LQSPL 736_ DPSTL 741_ LAEVC 746_ VEQCT 751_ FMDSK 756_ MKPLW 761_ IMYSN 766_ EEAGS 771_ GGSVG 776_ IIFKN 781_ GDDLR 786_ QDMLT 791_ LQMIQ 796_ LMDVL 801_ WKQEG 806_ LDLRM 811_ TPYGC 816_ LPTGD 821_ RTGLI 826_ EVVLR 831_ SDTIA 836_ NIQLN 841_ KSNMA 846_ ATAAF 851_ NKDAL 856_ LNWLK 861_ SKNPG 866_ EALDR 871_ AIEEF 876_ TLSCA 881_ GYCVA 886_ TYVLG 891_ IGDRH 896_ SDNIM 901_ IRESG 906_ QLFHI 911_ DFGHF 916_ LGNFK 921_ TKFGI 926_ NRERV 931_ PFILT 936_ YDFVH 941_ VIQQG 946_ KTNNS 951_ EKFER 956_ FRGYC 961_ ERAYT 966_ ILRRH 971_ GLLFL 976_ HLFAL 981_ MRAAG 986_ LPELS 991_ CSKDI 996_ QYLKD 1001_ SLALG 1006_ KTEEE 1011_ ALKHF 1016_ RVKFN 1021_ EALRE 1026_ SWKTK 1031_ VNWLA 1036_HNVSK
1: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity