Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.1) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2)
1_MALTS 6_ DLGKQ 11_ IKLKE 16_ VEGTL 21_ LQPAT 26_ VDNWS 31_ QIQSF 36_ EAKPD 41_ DLLIC 46_ TYPKA 51_ GTTWI 56_ QEIVD 61_ MIEQN 66_ GDVEK 71_ CQRAI 76_ IQHRH 81_ PFIEW 86_ ARPPQ 91_ PSGVE 96_ KAKAM 101_ PSPRI 106_ LKTHL 111_ STQLL 116_ PPSFW 121_ ENNCK 126_ FLYVA 131_ RNAKD 136_ CMVSY 141_ YHFQR 146_ MNHML 151_ PDPGT 156_ WEEYF 161_ ETFIN 166_ GKVVW 171_ GSWFD 176_ HVKGW 181_ WEMKD 186_ RHQIL 191_ FLFYE 196_ DIKRD 201_ PKHEI 206_ RKVMQ 211_ FMGKK 216_ VDETV 221_ LDKIV 226_ QETSF 231_ EKMKE 236_ NPMTN 241_ RSTVS 246_ KSILD 251_ QSISS 256_ FMRKG 261_ TVGDW 266_ KNHFT 271_ VAQNE 276_ RFDEI 281_ YRRKM 286_ EGTSI 291_NFCME
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds (PubMed:10481272, PubMed:10783263, PubMed:9852044). Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:10481272, PubMed:9852044). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity). Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044)