Neural Wiskott-Aldrich syndrome protein (N-WASP)
1_MSSVQ 6_ QQPPP 11_ PRRVT 16_ NVGSL 21_ LLTPQ 26_ ENESL 31_ FTFLG 36_ KKCVT 41_ MSSAV 46_ VQLYA 51_ ADRNC 56_ MWSKK 61_ CSGVA 66_ CLVKD 71_ NPQRS 76_ YFLRI 81_ FDIKD 86_ GKLLW 91_ EQELY 96_ NNFVY 101_ NSPRG 106_ YFHTF 111_ AGDTC 116_ QVALN 121_ FANEE 126_ EAKKF 131_ RKAVT 136_ DLLGR 141_ RQRKS 146_ EKRRD 151_ PPNGP 156_ NLPMA 161_ TVDIK 166_ NPEIT 171_ TNRFY 176_ GPQVN 181_ NISHT 186_ KEKKK 191_ GKAKK 196_ KRLTK 201_ ADIGT 206_ PSNFQ 211_ HIGHV 216_ GWDPN 221_ TGFDL 226_ NNLDP 231_ ELKNL 236_ FDMCG 241_ ISEAQ 246_ LKDRE 251_ TSKVI 256_ YDFIE 261_ KTGGV 266_ EAVKN 271_ ELRRQ 276_ APPPP 281_ PPSRG 286_ GPPPP 291_ PPPPH 296_ NSGPP 301_ PPPAR 306_ GRGAP 311_ PPPPS 316_ RAPTA 321_ APPPP 326_ PPSRP 331_ SVAVP 336_ PPPPN 341_ RMYPP 346_ PPPAL 351_ PSSAP 356_ SGPPP 361_ PPPSV 366_ LGVGP 371_ VAPPP 376_ PPPPP 381_ PPPGP 386_ PPPPG 391_ LPSDG 396_ DHQVP 401_ TTAGN 406_ KAALL 411_ DQIRE 416_ GAQLK 421_ KVEQN 426_ SRPVS 431_ CSGRD 436_ ALLDQ 441_ IRQGI 446_ QLKSV 451_ ADGQE 456_ STPPT 461_ PAPTS 466_ GIVGA 471_ LMEVM 476_ QKRSK 481_ AIHSS 486_ DEDED 491_ EDDEE 496_DFEDD
1: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742)