cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)
1_MGQAC 6_ GHSIL 11_ CRSQQ 16_ YPAAR 21_ PAEPR 26_ GQQVF 31_ LKPDE 36_ PPPPP 41_ QPCAD 46_ SLQDA 51_ LLSLG 56_ SVIDI 61_ SGLQR 66_ AVKEA 71_ LSAVL 76_ PRVET 81_ VYTYL 86_ LDGES 91_ QLVCE 96_ DPPHE 101_ LPQEG 106_ KVREA 111_ IISQK 116_ RLGCN 121_ GLGFS 126_ DLPGK 131_ PLARL 136_ VAPLA 141_ PDTQV 146_ LVMPL 151_ ADKEA 156_ GAVAA 161_ VILVH 166_ CGQLS 171_ DNEEW 176_ SLQAV 181_ EKHTL 186_ VALRR 191_ VQVLQ 196_ QRGPR 201_ EAPRA 206_ VQNPP 211_ EGTAE 216_ DQKGG 221_ AAYTD 226_ RDRKI 231_ LQLCG 236_ ELYDL 241_ DASSL 246_ QLKVL 251_ QYLQQ 256_ ETRAS 261_ RCCLL 266_ LVSED 271_ NLQLS 276_ CKVIG 281_ DKVLG 286_ EEVSF 291_ PLTGC 296_ LGQVV 301_ EDKKS 306_ IQLKD 311_ LTSED 316_ VQQLQ 321_ SMLGC 326_ ELQAM 331_ LCVPV 336_ ISRAT 341_ DQVVA 346_ LACAF 351_ NKLEG 356_ DLFTD 361_ EDEHV 366_ IQHCF 371_ HYTST 376_ VLTST 381_ LAFQK 386_ EQKLK 391_ CECQA 396_ LLQVA 401_ KNLFT 406_ HLDDV 411_ SVLLQ 416_ EIITE 421_ ARNLS 426_ NAEIC 431_ SVFLL 436_ DQNEL 441_ VAKVF 446_ DGGVV 451_ DDESY 456_ EIRIP 461_ ADQGI 466_ AGHVA 471_ TTGQI 476_ LNIPD 481_ AYAHP 486_ LFYRG 491_ VDDST 496_ GFRTR 501_ NILCF 506_ PIKNE 511_ NQEVI 516_ GVAEL 521_ VNKIN 526_ GPWFS 531_ KFDED 536_ LATAF 541_ SIYCG 546_ ISIAH 551_ SLLYK 556_ KVNEA 561_ QYRSH 566_ LANEM 571_ MMYHM 576_ KVSDD 581_ EYTKL 586_ LHDGI 591_ QPVAA 596_ IDSNF 601_ ASFTY 606_ TPRSL 611_ PEDDT 616_ SMAIL 621_ SMLQD 626_ MNFIN 631_ NYKID 636_ CPTLA 641_ RFCLM 646_ VKKGY 651_ RDPPY 656_ HNWMH 661_ AFSVS 666_ HFCYL 671_ LYKNL 676_ ELTNY 681_ LEDIE 686_ IFALF 691_ ISCMC 696_ HDLDH 701_ RGTNN 706_ SFQVA 711_ SKSVL 716_ AALYS 721_ SEGSV 726_ MERHH 731_ FAQAI 736_ AILNT 741_ HGCNI 746_ FDHFS 751_ RKDYQ 756_ RMLDL 761_ MRDII 766_ LATDL 771_ AHHLR 776_ IFKDL 781_ QKMAE 786_ VGYDR 791_ NNKQH 796_ HRLLL 801_ CLLMT 806_ SCDLS 811_ DQTKG 816_ WKTTR 821_ KIAEL 826_ IYKEF 831_ FSQGD 836_ LEKAM 841_ GNRPM 846_ EMMDR 851_ EKAYI 856_ PELQI 861_ SFMEH 866_ IAMPI 871_ YKLLQ 876_ DLFPK 881_ AAELY 886_ ERVAS 891_ NREHW 896_ TKVSH 901_ KFTIR 906_ GLPSN 911_ NSLDF 916_ LDEEY 921_ EVPDL 926_ DGTRA 931_ PINGC 936_CSLDA
1: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621). Plays a role in cell growth and migration (PubMed:24705027)
2: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107)