Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
1_MAAAA 6_ AEQQQ 11_ FYLLL 16_ GNLLS 21_ PDNVV 26_ RKQAE 31_ ETYEN 36_ IPGQS 41_ KITFL 46_ LQAIR 51_ NTTAA 56_ EEARQ 61_ MAAVL 66_ LRRLL 71_ SSAFD 76_ EVYPA 81_ LPSDV 86_ QTAIK 91_ SELLM 96_ IIQME 101_ TQSSM 106_ RKKVC 111_ DIAAE 116_ LARNL 121_ IDEDG 126_ NNQWP 131_ EGLKF 136_ LFDSV 141_ SSQNV 146_ GLREA 151_ ALHIF 156_ WNFPG 161_ IFGNQ 166_ QQHYL 171_ DVIKR 176_ MLVQC 181_ MQDQE 186_ HPSIR 191_ TLSAR 196_ ATAAF 201_ ILANE 206_ HNVAL 211_ FKHFA 216_ DLLPG 221_ FLQAV 226_ NDSCY 231_ QNDDS 236_ VLKSL 241_ VEIAD 246_ TVPKY 251_ LRPHL 256_ EATLQ 261_ LSLKL 266_ CGDTS 271_ LNNMQ 276_ RQLAL 281_ EVIVT 286_ LSETA 291_ AAMLR 296_ KHTNI 301_ VAQTI 306_ PQMLA 311_ MMVDL 316_ EEDED 321_ WANAD 326_ ELEDD 331_ DFDSN 336_ AVAGE 341_ SALDR 346_ MACGL 351_ GGKLV 356_ LPMIK 361_ EHIMQ 366_ MLQNP 371_ DWKYR 376_ HAGLM 381_ ALSAI 386_ GEGCH 391_ QQMEG 396_ ILNEI 401_ VNFVL 406_ LFLQD 411_ PHPRV 416_ RYAAC 421_ NAVGQ 426_ MATDF 431_ APGFQ 436_ KKFHE 441_ KVIAA 446_ LLQTM 451_ EDQGN 456_ QRVQA 461_ HAAAA 466_ LINFT 471_ EDCPK 476_ SLLIP 481_ YLDNL 486_ VKHLH 491_ SIMVL 496_ KLQEL 501_ IQKGT 506_ KLVLE 511_ QVVTS 516_ IASVA 521_ DTAEE 526_ KFVPY 531_ YDLFM 536_ PSLKH 541_ IVENA 546_ VQKEL 551_ RLLRG 556_ KTIEC 561_ ISLIG 566_ LAVGK 571_ EKFMQ 576_ DASDV 581_ MQLLL 586_ KTQTD 591_ FNDME 596_ DDDPQ 601_ ISYMI 606_ SAWAR 611_ MCKIL 616_ GKEFQ 621_ QYLPV 626_ VMGPL 631_ MKTAS 636_ IKPEV 641_ ALLDT 646_ QDMEN 651_ MSDDD 656_ GWEFV 661_ NLGDQ 666_ QSFGI 671_ KTAGL 676_ EEKST 681_ ACQML 686_ VCYAK 691_ ELKEG 696_ FVEYT 701_ EQVVK 706_ LMVPL 711_ LKFYF 716_ HDGVR 721_ VAAAE 726_ SMPLL 731_ LECAR 736_ VRGPE 741_ YLTQM 746_ WHFMC 751_ DALIK 756_ AIGTE 761_ PDSDV 766_ LSEIM 771_ HSFAK 776_ CIEVM 781_ GDGCL 786_ NNEHF 791_ EELGG 796_ ILKAK 801_ LEEHF 806_ KNQEL 811_ RQVKR 816_ QDEDY 821_ DEQVE 826_ ESLQD 831_ EDDND 836_ VYILT 841_ KVSDI 846_ LHSIF 851_ SSYKE 856_ KVLPW 861_ FEQLL 866_ PLIVN 871_ LICPH 876_ RPWPD 881_ RQWGL 886_ CIFDD 891_ VIEHC 896_ SPASF 901_ KYAEY 906_ FLRPM 911_ LQYVC 916_ DNSPE 921_ VRQAA 926_ AYGLG 931_ VMAQY 936_ GGDNY 941_ RPFCT 946_ EALPL 951_ LVRVI 956_ QSADS 961_ KTKEN 966_ VNATE 971_ NCISA 976_ VGKIM 981_ KFKPD 986_ CVNVE 991_ EVLPH 996_ WLSWL 1001_ PLHED 1006_ KEEAV 1011_ QTFNY 1016_ LCDLI 1021_ ESNHP 1026_ IVLGP 1031_ NNTNL 1036_ PKIFS 1041_ IIAEG 1046_ EMHEA 1051_ IKHED 1056_ PCAKR 1061_ LANVV 1066_ RQVQT 1071_ SGGLW 1076_ TECIA 1081_ QLSPE 1086_ QQAAI 1091_QELLN
1: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev