DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)
1_MSALC 6_ WGRGA 11_ AGLKR 16_ ALRPC 21_ GRPGL 26_ PGKEG 31_ TAGGV 36_ CGPRR 41_ SSSAS 46_ PQEQD 51_ QDRRK 56_ DWGHV 61_ ELLEV 66_ LQARV 71_ RQLQA 76_ ESVSE 81_ VVVNR 86_ VDVAR 91_ LPECG 96_ SGDGS 101_ LQPPR 106_ KVQMG 111_ AKDAT 116_ PVPCG 121_ RWAKI 126_ LEKDK 131_ RTQQM 136_ RMQRL 141_ KAKLQ 146_ MPFQS 151_ GEFKA 156_ LTRRL 161_ QVEPR 166_ LLSKQ 171_ MAGCL 176_ EDCTR 181_ QAPES 186_ PWEEQ 191_ LARLL 196_ QEAPG 201_ KLSLD 206_ VEQAP 211_ SGQHS 216_ QAQLS 221_ GQQQR 226_ LLAFF 231_ KCCLL 236_ TDQLP 241_ LAHHL 246_ LVVHH 251_ GQRQK 256_ RKLLT 261_ LDMYN 266_ AVMLG 271_ WARQG 276_ AFKEL 281_ VYVLF 286_ MVKDA 291_ GLTPD 296_ LLSYA 301_ AALQC 306_ MGRQD 311_ QDAGT 316_ IERCL 321_ EQMSQ 326_ EGLKL 331_ QALFT 336_ AVLLS 341_ EEDRA 346_ TVLKA 351_ VHKVK 356_ PTFSL 361_ PPQLP 366_ PPVNT 371_ SKLLR 376_ DVYAK 381_ DGRVS 386_ YPKLH 391_ LPLKT 396_ LQCLF 401_ EKQLH 406_ MELAS 411_ RVCVV 416_ SVEKP 421_ TLPSK 426_ EVKHA 431_ RKTLK 436_ TLRDQ 441_ WEKAL 446_ CRALR 451_ ETKNR 456_ LEREV 461_ YEGRF 466_ SLYPF 471_ LCLLD 476_ EREVV 481_ RMLLQ 486_ VLQAL 491_ PAQGE 496_ SFTTL 501_ ARELS 506_ ARTFS 511_ RHVVQ 516_ RQRVS 521_ GQVQA 526_ LQNHY 531_ RKYLC 536_ LLASD 541_ AEVPE 546_ PCLPR 551_ QYWEE 556_ LGAPE 561_ ALREQ 566_ PWPLP 571_ VQMEL 576_ GKLLA 581_ EMLVQ 586_ ATQMP 591_ CSLDK 596_ PHRSS 601_ RLVPV 606_ LYHVY 611_ SFRNV 616_ QQIGI 621_ LKPHP 626_ AYVQL 631_ LEKAA 636_ EPTLT 641_ FEAVD 646_ VPMLC 651_ PPLPW 656_ TSPHS 661_ GAFLL 666_ SPTKL 671_ MRTVE 676_ GATQH 681_ QELLE 686_ TCPPT 691_ ALHGA 696_ LDALT 701_ QLGNC 706_ AWRVN 711_ GRVLD 716_ LVLQL 721_ FQAKG 726_ CPQLG 731_ VPAPP 736_ SEAPQ 741_ PPEAH 746_ LPHSA 751_ APARK 756_ AELRR 761_ ELAHC 766_ QKVAR 771_ EMHSL 776_ RAEAL 781_ YRLSL 786_ AQHLR 791_ DRVFW 796_ LPHNM 801_ DFRGR 806_ TYPCP 811_ PHFNH 816_ LGSDV 821_ ARALL 826_ EFAQG 831_ RPLGP 836_ HGLDW 841_ LKIHL 846_ VNLTG 851_ LKKRE 856_ PLRKR 861_ LAFAE 866_ EVMDD 871_ ILDSA 876_ DQPLT 881_ GRKWW 886_ MGAEE 891_ PWQTL 896_ ACCME 901_ VANAV 906_ RASDP 911_ AAYVS 916_ HLPVH 921_ QDGSC 926_ NGLQH 931_ YAALG 936_ RDSVG 941_ AASVN 946_ LEPSD 951_ VPQDV 956_ YSGVA 961_ AQVEV 966_ FRRQD 971_ AQRGM 976_ RVAQV 981_ LEGFI 986_ TRKVV 991_ KQTVM 996_ TVVYG 1001_ VTRYG 1006_ GRLQI 1011_ EKRLR 1016_ ELSDF 1021_ PQEFV 1026_ WEASH 1031_ YLVRQ 1036_ VFKSL 1041_ QEMFS 1046_ GTRAI 1051_ QHWLT 1056_ ESARL 1061_ ISHMG 1066_ SVVEW 1071_ VTPLG 1076_ VPVIQ 1081_ PYRLD 1086_ SKVKQ 1091_ IGGGI 1096_ QSITY 1101_ THNGD 1106_ ISRKP 1111_ NTRKQ 1116_ KNGFP 1121_ PNFIH 1126_ SLDSS 1131_ HMMLT 1136_ ALHCY 1141_ RKGLT 1146_ FVSVH 1151_ DCYWT 1156_ HAADV 1161_ SVMNQ 1166_ VCREQ 1171_ FVRLH 1176_ SEPIL 1181_ QDLSR 1186_ FLVKR 1191_ FCSEP 1196_ QKILE 1201_ ASQLK 1206_ ETLQA 1211_ VPKPG 1216_ AFDLE 1221_QVKRS
1: DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924)