Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)
1_MADED 6_ LIFRL 11_ EGVDG 16_ GQSPR 21_ AGHDG 26_ DSDGD 31_ SDDEE 36_ GYFIC 41_ PITDD 46_ PSSNQ 51_ NVNSK 56_ VNKYY 61_ SNLTK 66_ SERYS 71_ SSGSP 76_ ANSFH 81_ FKEAW 86_ KHAIQ 91_ KAKHM 96_ PDPWA 101_ EFHLE 106_ DIATE 111_ RATRH 116_ RYNAV 121_ TGEWL 126_ DDEVL 131_ IKMAS 136_ QPFGR 141_ GAMRE 146_ CFRTK 151_ KLSNF 156_ LHAQQ 161_ WKGAS 166_ NYVAK 171_ RYIEP 176_ VDRDV 181_ YFEDV 186_ RLQME 191_ AKLWG 196_ EEYNR 201_ HKPPK 206_ QVDIM 211_ QMCII 216_ ELKDR 221_ PGKPL 226_ FHLEH 231_ YIEGK 236_ YIKYN 241_ SNSGF 246_ VRDDN 251_ IRLTP 256_ QAFSH 261_ FTFER 266_ SGHQL 271_ IVVDI 276_ QGVGD 281_ LYTDP 286_ QIHTE 291_ TGTDF 296_ GDGNL 301_ GVRGM 306_ ALFFY 311_ SHACN 316_ RICES 321_ MGLAP 326_ FDLSP 331_ RERDA 336_ VNQNT 341_ KLLQS 346_ AKTIL 351_ RGTEE 356_ KCGSP 361_ QVRTL 366_ SGSRP 371_ PLLRP 376_ LSENS 381_ GDENM 386_ SDVTF 391_ DSLPS 396_ SPSSA 401_ TPHSQ 406_ KLDHL 411_ HWPVF 416_ SDLDN 421_ MASRD 426_ HDHLD 431_ NHRES 436_ ENSGD 441_ SGYPS 446_ EKRGE 451_ LDDPE 456_ PREHG 461_ HSYSN 466_ RKYES 471_ DEDSL 476_ GSSGR 481_ VCVEK 486_ WNLLN 491_ SSRLH 496_ LPRAS 501_ AVALE 506_ VQRLN 511_ ALDLE 516_ KKIGK 521_ SILGK 526_ VHLAM 531_ VRYHE 536_ GGRFC 541_ EKGEE 546_ WDQES 551_ AVFHL 556_ EHAAN 561_ LGELE 566_ AIVGL 571_ GLMYS 576_ QLPHH 581_ ILADV 586_ SLKET 591_ EENKT 596_ KGFDY 601_ LLKAA 606_ EAGDR 611_ QSMIL 616_ VARAF 621_ DSGQN 626_ LSPDR 631_ CQDWL 636_ EALHW 641_ YNTAL 646_ EMTDC 651_ DEGGE 656_ YDGMQ 661_ DEPRY 666_ MMLAR 671_ EAEML 676_ FTGGY 681_ GLEKD 686_ PQRSG 691_ DLYTQ 696_ AAEAA 701_ MEAMK 706_ GRLAN 711_ QYYQK 716_AEEAW
1: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced