Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)
1_MAVES 6_ RVTQE 11_ EIKKE 16_ PEKPI 21_ DREKT 26_ CPLLL 31_ RVFTT 36_ NNGRH 41_ HRMDE 46_ FSRGN 51_ VPSSE 56_ LQIYT 61_ WMDAT 66_ LKELT 71_ SLVKE 76_ VYPEA 81_ RKKGT 86_ HFNFA 91_ IVFTD 96_ VKRPG 101_ YRVKE 106_ IGSTM 111_ SGRKG 116_ TDDSM 121_ TLQSQ 126_ KFQIG 131_ DYLDI 136_ AITPP 141_ NRAPP 146_PSGRM
1: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function