Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
1_MNKLY 6_ IGNLS 11_ ENAAP 16_ SDLES 21_ IFKDA 26_ KIPVS 31_ GPFLV 36_ KTGYA 41_ FVDCP 46_ DESWA 51_ LKAIE 56_ ALSGK 61_ IELHG 66_ KPIEV 71_ EHSVP 76_ KRQRI 81_ RKLQI 86_ RNIPP 91_ HLQWE 96_ VLDSL 101_ LVQYG 106_ VVESC 111_ EQVNT 116_ DSETA 121_ VVNVT 126_ YSSKD 131_ QARQA 136_ LDKLN 141_ GFQLE 146_ NFTLK 151_ VAYIP 156_ DEMAA 161_ QQNPL 166_ QQPRG 171_ RRGLG 176_ QRGSS 181_ RQGSP 186_ GSVSK 191_ QKPCD 196_ LPLRL 201_ LVPTQ 206_ FVGAI 211_ IGKEG 216_ ATIRN 221_ ITKQT 226_ QSKID 231_ VHRKE 236_ NAGAA 241_ EKSIT 246_ ILSTP 251_ EGTSA 256_ ACKSI 261_ LEIMH 266_ KEAQD 271_ IKFTE 276_ EIPLK 281_ ILAHN 286_ NFVGR 291_ LIGKE 296_ GRNLK 301_ KIEQD 306_ TDTKI 311_ TISPL 316_ QELTL 321_ YNPER 326_ TITVK 331_ GNVET 336_ CAKAE 341_ EEIMK 346_ KIRES 351_ YENDI 356_ ASMNL 361_ QAHLI 366_ PGLNL 371_ NALGL 376_ FPPTS 381_ GMPPP 386_ TSGPP 391_ SAMTP 396_ PYPQF 401_ EQSET 406_ ETVHL 411_ FIPAL 416_ SVGAI 421_ IGKQG 426_ QHIKQ 431_ LSRFA 436_ GASIK 441_ IAPAE 446_ APDAK 451_ VRMVI 456_ ITGPP 461_ EAQFK 466_ AQGRI 471_ YGKIK 476_ EENFV 481_ SPKEE 486_ VKLEA 491_ HIRVP 496_ SFAAG 501_ RVIGK 506_ GGKTV 511_ NELQN 516_ LSSAE 521_ VVVPR 526_ DQTPD 531_ ENDQV 536_ VVKIT 541_ GHFYA 546_ CQVAQ 551_ RKIQE 556_ ILTQV 561_ KQHQQ 566_ QKALQ 571_SGPPQ
1: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs