RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1)
1_MAGPR 6_ VEVDG 11_ SIMEG 16_ GGQIL 21_ RVSTA 26_ LSCLL 31_ GLPLR 36_ VQKIR 41_ AGRST 46_ PGLRP 51_ QHLSG 56_ LEMIR 61_ DLCDG 66_ QLEGA 71_ EIGST 76_ EITFT 81_ PEKIK 86_ GGIHT 91_ ADTKT 96_ AGSVC 101_ LLMQV 106_ SMPCV 111_ LFAAS 116_ PSELH 121_ LKGGT 126_ NAEMA 131_ PQIDY 136_ TVMVF 141_ KPIVE 146_ KFGFI 151_ FNCDI 156_ KTRGY 161_ YPKGG 166_ GEVIV 171_ RMSPV 176_ KQLNP 181_ INLTE 186_ RGCVT 191_ KIYGR 196_ AFVAG 201_ VLPFK 206_ VAKDM 211_ AAAAV 216_ RCIRK 221_ EIRDL 226_ YVNIQ 231_ PVQEP 236_ KDQAF 241_ GNGNG 246_ IIIIA 251_ ETSTG 256_ CLFAG 261_ SSLGK 266_ RGVNA 271_ DKVGI 276_ EAAEM 281_ LLANL 286_ RHGGT 291_ VDEYL 296_ QDQLI 301_ VFMAL 306_ ANGVS 311_ RIKTG 316_ PVTLH 321_ TQTAI 326_ HFAEQ 331_ IAKAK 336_ FIVKK 341_ SEDEE 346_ DAAKD 351_ TYIIE 356_ CQGIG 361_MTNPN
1: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (PubMed:9184239). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (PubMed:9184239). Likely functions in some aspects of cellular RNA processing (PubMed:25961792, PubMed:9184239). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792)