Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)
1_MAQIS 6_ SNSGF 11_ KECPS 16_ SHPEP 21_ TRAKD 26_ VDKEE 31_ ALQME 36_ AEALA 41_ KLQKD 46_ RQVTD 51_ NQRGF 56_ ELSSS 61_ TRKKA 66_ QVYNK 71_ QDYDL 76_ MVFPE 81_ SDSQK 86_ RALDI 91_ DVEKL 96_ TQAEL 101_ EKLLL 106_ DDSFE 111_ TKKTP 116_ VLPVT 121_ PILSP 126_ SFSAQ 131_ LYFRP 136_ TIQRG 141_ QWPPG 146_ LPGPS 151_ TYALP 156_ SIYPS 161_ TYSKQ 166_ AAFQN 171_ GFNPR 176_ MPTFP 181_ STEPI 186_ YLSLP 191_ GQSPY 196_ FSYPL 201_ TPATP 206_ FHPQG 211_ SLPIY 216_ RPVVS 221_ TDMAK 226_ LFDKI 231_ ASTSE 236_ FLKNG 241_ KARTD 246_ LEITD 251_ SKVSN 256_ LQVSP 261_ KSEDI 266_ SKFDW 271_ LDLDP 276_ LSKPK 281_ VDNVE 286_ VLDHE 291_ EEKNV 296_ SSLLA 301_ KDPWD 306_ AVLLE 311_ ERSTA 316_ NCHLE 321_ RKVNG 326_ KSLSV 331_ ATVTR 336_ SQSLN 341_ IRTTQ 346_ LAKAQ 351_ GHISQ 356_ KDPNG 361_ TSSLP 366_ TGSSL 371_ LQEVE 376_ VQNEE 381_ MAAFC 386_ RSITK 391_ LKTKF 396_ PYTNH 401_ RTNPG 406_ YLLSP 411_ VTAQR 416_ NICGE 421_ NASVK 426_ VSIDI 431_ EGFQL 436_ PVTFT 441_ CDVSS 446_ TVEII 451_ IMQAL 456_ CWVHD 461_ DLNQV 466_ DVGSY 471_ VLKVC 476_ GQEEV 481_ LQNNH 486_ CLGSH 491_ EHIQN 496_ CRKWD 501_ TEIRL 506_ QLLTF 511_ SAMCQ 516_ NLART 521_ AEDDE 526_ TPVDL 531_ NKHLY 536_ QIEKP 541_ CKEAM 546_ TRHPV 551_ EELLD 556_ SYHNQ 561_ VELAL 566_ QIENQ 571_ HRAVD 576_ QVIKA 581_ VRKIC 586_ SALDG 591_ VETLA 596_ ITESV 601_ KKLKR 606_ AVNLP 611_ RSKTA 616_ DVTSL 621_ FGGED 626_ TSRSS 631_ TRGSL 636_ NPENP 641_ VQVSI 646_ NQLTA 651_ AIYDL 656_ LRLHA 661_ NSGRS 666_ PTDCA 671_ QSSKS 676_ VKEAW 681_ TTTEQ 686_ LQFTI 691_ FAAHG 696_ ISSNW 701_ VSNYE 706_ KYYLI 711_ CSLSH 716_ NGKDL 721_ FKPIQ 726_ SKKVG 731_ TYKNF 736_ FYLIK 741_ WDELI 746_ IFPIQ 751_ ISQLP 756_ LESVL 761_ HLTLF 766_ GILNQ 771_ SSGSS 776_ PDSNK 781_ QRKGP 786_ EALGK 791_ VSLPL 796_ FDFKR 801_ FLTCG 806_ TKLLY 811_ LWTSS 816_ HTNSV 821_ PGTVT 826_ KKGYV 831_ MERIV 836_ LQVDF 841_ PSPAF 846_ DIIYT 851_ TPQVD 856_ RSIIQ 861_ QHNLE 866_ TLEND 871_ IKGKL 876_ LDILH 881_ KDSSL 886_ GLSKE 891_ DKAFL 896_ WEKRY 901_ YCFKH 906_ PNCLP 911_ KILAS 916_ APNWK 921_ WVNLA 926_ KTYSL 931_ LHQWP 936_ ALYPL 941_ IALEL 946_ LDSKF 951_ ADQEV 956_ RSLAV 961_ TWIEA 966_ ISDDE 971_ LTDLL 976_ PQFVQ 981_ ALKYE 986_ IYLNS 991_ SLVQF 996_ LLSRA 1001_ LGNIQ 1006_ IAHNL 1011_ YWLLK 1016_ DALHD 1021_ VQFST 1026_ RYEHV 1031_ LGALL 1036_ SVGGK 1041_ RLREE 1046_ LLKQT 1051_ KLVQL 1056_ LGGVA 1061_ EKVRQ 1066_ ASGSA 1071_ RQVVL 1076_ QRSME 1081_ RVQSF 1086_ FQKNK 1091_ CRLPL 1096_ KPSLV 1101_ AKELN 1106_ IKSCS 1111_ FFSSN 1116_ AVPLK 1121_ VTMVN 1126_ ADPMG 1131_ EEINV 1136_ MFKVG 1141_ EDLRQ 1146_ DMLAL 1151_ QMIKI 1156_ MDKIW 1161_ LKEGL 1166_ DLRMV 1171_ IFKCL 1176_ STGRD 1181_ RGMVE 1186_ LVPAS 1191_ DTLRK 1196_ IQVEY 1201_ GVTGS 1206_ FKDKP 1211_ LAEWL 1216_ RKYNP 1221_ SEEEY 1226_ EKASE 1231_ NFIYS 1236_ CAGCC 1241_ VATYV 1246_ LGICD 1251_ RHNDN 1256_ IMLRS 1261_ TGHMF 1266_ HIDFG 1271_ KFLGH 1276_ AQMFG 1281_ SFKRD 1286_ RAPFV 1291_ LTSDM 1296_ AYVIN 1301_ GGEKP 1306_ TIRFQ 1311_ LFVDL 1316_ CCQAY 1321_ NLIRK 1326_ QTNLF 1331_ LNLLS 1336_ LMIPS 1341_ GLPEL 1346_ TSIQD 1351_ LKYVR 1356_ DALQP 1361_ QTTDA 1366_ EATIF 1371_ FTRLI 1376_ ESSLG 1381_ SIATK 1386_ FNFFI 1391_ HNLAQ 1396_ LRFSG 1401_ LPSND 1406_ EPILS 1411_ FSPKT 1416_ YSFRQ 1421_ DGRIK 1426_ EVSVF 1431_ TYHKK 1436_ YNPDK 1441_ HYIYV 1446_ VRILR 1451_ EGQIE 1456_ PSFVF 1461_ RTFDE 1466_ FQELH 1471_ NKLSI 1476_ IFPLW 1481_ KLPGF 1486_ PNRMV 1491_ LGRTH 1496_ IKDVA 1501_ AKRKI 1506_ ELNSY 1511_ LQSLM 1516_ NASTD 1521_ VAECD 1526_ LVCTF 1531_ FHPLL 1536_ RDEKA 1541_ EGIAR 1546_ SADAG 1551_ SFSPT 1556_ PGQIG 1561_ GAVKL 1566_ SISYR 1571_ NGTLF 1576_ IMVMH 1581_ IKDLV 1586_ TEDGA 1591_ DPNPY 1596_ VKTYL 1601_ LPDNH 1606_ KTSKR 1611_ KTKIS 1616_ RKTRN 1621_ PTFNE 1626_ MLVYS 1631_ GYSKE 1636_ TLRQR 1641_ ELQLS 1646_ VLSAE 1651_ SLREN 1656_ FFLGG 1661_ VTLPL 1666_ KDFNL 1671_ SKETV 1676_ KWYQL 1681_TAATY
1: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465)