Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
1_MATCI 6_ GEKIE 11_ DFKVG 16_ NLLGK 21_ GSFAG 26_ VYRAE 31_ SIHTG 36_ LEVAI 41_ KMIDK 46_ KAMYK 51_ AGMVQ 56_ RVQNE 61_ VKIHC 66_ QLKHP 71_ SILEL 76_ YNYFE 81_ DSNYV 86_ YLVLE 91_ MCHNG 96_ EMNRY 101_ LKNRV 106_ KPFSE 111_ NEARH 116_ FMHQI 121_ ITGML 126_ YLHSH 131_ GILHR 136_ DLTLS 141_ NLLLT 146_ RNMNI 151_ KIADF 156_ GLATQ 161_ LKMPH 166_ EKHYT 171_ LCGTP 176_ NYISP 181_ EIATR 186_ SAHGL 191_ ESDVW 196_ SLGCM 201_ FYTLL 206_ IGRPP 211_ FDTDT 216_ VKNTL 221_ NKVVL 226_ ADYEM 231_ PSFLS 236_ IEAKD 241_ LIHQL 246_ LRRNP 251_ ADRLS 256_ LSSVL 261_ DHPFM 266_ SRNSS 271_ TKSKD 276_ LGTVE 281_ DSIDS 286_ GHATI 291_ STAIT 296_ ASSST 301_ SISGS 306_ LFDKR 311_ RLLIG 316_ QPLPN 321_ KMTVF 326_ PKNKS 331_ STDFS 336_ SSGDG 341_ NSFYT 346_ QWGNQ 351_ ETSNS 356_ GRGRV 361_ IQDAE 366_ ERPHS 371_ RYLRR 376_ AYSSD 381_ RSGTS 386_ NSQSQ 391_ AKTYT 396_ MERCH 401_ SAEML 406_ SVSKR 411_ SGGGE 416_ NEERY 421_ SPTDN 426_ NANIF 431_ NFFKE 436_ KTSSS 441_ SGSFE 446_ RPDNN 451_ QALSN 456_ HLCPG 461_ KTPFP 466_ FADPT 471_ PQTET 476_ VQQWF 481_ GNLQI 486_ NAHLR 491_ KTTEY 496_ DSISP 501_ NRDFQ 506_ GHPDL 511_ QKDTS 516_ KNAWT 521_ DTKVK 526_ KNSDA 531_ SDNAH 536_ SVKQQ 541_ NTMKY 546_ MTALH 551_ SKPEI 556_ IQQEC 561_ VFGSD 566_ PLSEQ 571_ SKTRG 576_ MEPPW 581_ GYQNR 586_ TLRSI 591_ TSPLV 596_ AHRLK 601_ PIRQK 606_ TKKAV 611_ VSILD 616_ SEEVC 621_ VELVK 626_ EYASQ 631_ EYVKE 636_ VLQIS 641_ SDGNT 646_ ITIYY 651_ PNGGR 656_ GFPLA 661_ DRPPS 666_ PTDNI 671_ SRYSF 676_ DNLPE 681_ KYWRK 686_ YQYAS 691_ RFVQL 696_ VRSKS 701_ PKITY 706_ FTRYA 711_ KCILM 716_ ENSPG 721_ ADFEV 726_ WFYDG 731_ VKIHK 736_ TEDFI 741_ QVIEK 746_ TGKSY 751_ TLKSE 756_ SEVNS 761_ LKEEI 766_ KMYMD 771_ HANEG 776_ HRICL 781_ ALESI 786_ ISEEE 791_ RKTRS 796_ APFFP 801_ IIIGR 806_ KPGST 811_ SSPKA 816_ LSPPP 821_ SVDSN 826_ YPTRE 831_ RASFN 836_ RMVMH 841_ SAASP 846_ TQAPI 851_ LNPSM 856_ VTNEG 861_ LGLTT 866_ TASGT 871_ DISSN 876_ SLKDC 881_ LPKSA 886_ QLLKS 891_ VFVKN 896_ VGWAT 901_ QLTSG 906_ AVWVQ 911_ FNDGS 916_ QLVVQ 921_ AGVSS 926_ ISYTS 931_ PNGQT 936_ TRYGE 941_ NEKLP 946_ DYIKQ 951_ KLQCL 956_ SSILL 961_MFSNP
1: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208)