Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
1_MAGPE 6_ GFQYR 11_ ALYPF 16_ RRERP 21_ EDLEL 26_ LPGDV 31_ LVVSR 36_ AALQA 41_ LGVAE 46_ GGERC 51_ PQSVG 56_ WMPGL 61_ NERTR 66_ QRGDF 71_ PGTYV 76_ EFLGP 81_ VALAR 86_ PGPRP 91_ RGPRP 96_ LPARP 101_ RDGAP 106_ EPGLT 111_ LPDLP 116_ EQFSP 121_ PDVAP 126_ PLLVK 131_ LVEAI 136_ ERTGL 141_ DSESH 146_ YRPEL 151_ PAPRT 156_ DWSLS 161_ DVDQW 166_ DTAAL 171_ ADGIK 176_ SFLLA 181_ LPAPL 186_ VTPEA 191_ SAEAR 196_ RALRE 201_ AAGPV 206_ GPALE 211_ PPTLP 216_ LHRAL 221_ TLRFL 226_ LQHLG 231_ RVASR 236_ APALG 241_ PAVRA 246_ LGATF 251_ GPLLL 256_ RAPPP 261_ PSSPP 266_ PGGAP 271_ DGSEP 276_ SPDFP 281_ ALLVE 286_ KLLQE 291_ HLEEQ 296_ EVAPP 301_ ALPPK 306_ PPKAK 311_ PASTV 316_ LANGG 321_ SPPSL 326_ QDAEW 331_ YWGDI 336_ SREEV 341_ NEKLR 346_ DTPDG 351_ TFLVR 356_ DASSK 361_ IQGEY 366_ TLTLR 371_ KGGNN 376_ KLIKV 381_ FHRDG 386_ HYGFS 391_ EPLTF 396_ CSVVD 401_ LINHY 406_ RHESL 411_ AQYNA 416_ KLDTR 421_ LLYPV 426_ SKYQQ 431_ DQIVK 436_ EDSVE 441_ AVGAQ 446_ LKVYH 451_ QQYQD 456_ KSREY 461_ DQLYE 466_ EYTRT 471_ SQELQ 476_ MKRTA 481_ IEAFN 486_ ETIKI 491_ FEEQG 496_ QTQEK 501_ CSKEY 506_ LERFR 511_ REGNE 516_ KEMQR 521_ ILLNS 526_ ERLKS 531_ RIAEI 536_ HESRT 541_ KLEQQ 546_ LRAQA 551_ SDNRE 556_ IDKRM 561_ NSLKP 566_ DLMQL 571_ RKIRD 576_ QYLVW 581_ LTQKG 586_ ARQKK 591_ INEWL 596_ GIKNE 601_ TEDQY 606_ ALMED 611_ EDDLP 616_ HHEER 621_ TWYVG 626_ KINRT 631_ QAEEM 636_ LSGKR 641_ DGTFL 646_ IRESS 651_ QRGCY 656_ ACSVV 661_ VDGDT 666_ KHCVI 671_ YRTAT 676_ GFGFA 681_ EPYNL 686_ YGSLK 691_ ELVLH 696_ YQHAS 701_ LVQHN 706_ DALTV 711_ TLAHP 716_ VRAPG 721_PGPPP
1: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity)