RNA polymerase II elongation factor ELL2
1_MAAGG 6_ TGGLR 11_ EEQRY 16_ GLSCG 21_ RLGQD 26_ NITVL 31_ HVKLT 36_ ETAIR 41_ ALETY 46_ QSHKN 51_ LIPFR 56_ PSIQF 61_ QGLHG 66_ LVKIP 71_ KNDPL 76_ NEVHN 81_ FNFYL 86_ SNVGK 91_ DNPQG 96_ SFDCI 101_ QQTFS 106_ SSGAS 111_ QLNCL 116_ GFIQD 121_ KITVC 126_ ATNDS 131_ YQMTR 136_ ERMTQ 141_ AEEES 146_ RNRST 151_ KVIKP 156_ GGPYV 161_ GKRVQ 166_ IRKAP 171_ QAVSD 176_ TVPER 181_ KRSTP 186_ MNPAN 191_ TIRKT 196_ HSSST 201_ ISQRP 206_ YRDRV 211_ IHLLA 216_ LKAYK 221_ KPELL 226_ ARLQK 231_ DGVNQ 236_ KDKNS 241_ LGAIL 246_ QQVAN 251_ LNSKD 256_ LSYTL 261_ KDYVF 266_ KELQR 271_ DWPGY 276_ SEIDR 281_ RSLES 286_ VLSRK 291_ LNPSQ 296_ NAAGT 301_ SRSES 306_ PVCSS 311_ RDAVS 316_ SPQKR 321_ LLDSE 326_ FIDPL 331_ MNKKA 336_ RISHL 341_ TNRVP 346_ PTLNG 351_ HLNPT 356_ SEKSA 361_ AGLPL 366_ PPAAA 371_ AIPTP 376_ PPLPS 381_ TYLPI 386_ SHPPQ 391_ IVNSN 396_ SNSPS 401_ TPEGR 406_ GTQDL 411_ PVDSF 416_ SQNDS 421_ IYEDQ 426_ QDKYT 431_ SRTSL 436_ ETLPP 441_ GSVLL 446_ KCPKP 451_ MEENH 456_ SMSHK 461_ KSKKK 466_ SKKHK 471_ EKDQI 476_ KKHDI 481_ ETIEE 486_ KEEDL 491_ KREEE 496_ IAKLN 501_ NSSPN 506_ SSGGV 511_ KEDCT 516_ ASMEP 521_ SAIEL 526_ PDYLI 531_ KYIAI 536_ VSYEQ 541_ RQNYK 546_ DDFNA 551_ EYDEY 556_ RALHA 561_ RMETV 566_ ARRFI 571_ KLDAQ 576_ RKRLS 581_ PGSKE 586_ YQNVH 591_ EEVLQ 596_ EYQKI 601_ KQSSP 606_ NYHEE 611_ KYRCE 616_ YLHNK 621_ LAHIK 626_ RLIGE 631_FDQQQ
1: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression