26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)
1_MDRLL 6_ RLGGG 11_ MPGLG 16_ QGPPT 21_ DAPAV 26_ DTAEQ 31_ VYISS 36_ LALLK 41_ MLKHG 46_ RAGVP 51_ MEVMG 56_ LMLGE 61_ FVDDY 66_ TVRVI 71_ DVFAM 76_ PQSGT 81_ GVSVE 86_ AVDPV 91_ FQAKM 96_ LDMLK 101_ QTGRP 106_ EMVVG 111_ WYHSH 116_ PGFGC 121_ WLSGV 126_ DINTQ 131_ QSFEA 136_ LSERA 141_ VAVVV 146_ DPIQS 151_ VKGKV 156_ VIDAF 161_ RLINA 166_ NMMVL 171_ GHEPR 176_ QTTSN 181_ LGHLN 186_ KPSIQ 191_ ALIHG 196_ LNRHY 201_ YSITI 206_ NYRKN 211_ ELEQK 216_ MLLNL 221_ HKKSW 226_ MEGLT 231_ LQDYS 236_ EHCKH 241_ NESVV 246_ KEMLE 251_ LAKNY 256_ NKAVE 261_ EEDKM 266_ TPEQL 271_ AIKNV 276_ GKQDP 281_ KRHLE 286_ EHVDV 291_ LMTSN 296_ IVQCL 301_AAMLD
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading