Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)
1_MAEMG 6_ SKGVT 11_ AGKIA 16_ SNVQK 21_ KLTRA 26_ QEKVL 31_ QKLGK 36_ ADETK 41_ DEQFE 46_ QCVQN 51_ FNKQL 56_ TEGTR 61_ LQKDL 66_ RTYLA 71_ SVKAM 76_ HEASK 81_ KLNEC 86_ LQEVY 91_ EPDWP 96_ GRDEA 101_ NKIAE 106_ NNDLL 111_ WMDYH 116_ QKLVD 121_ QALLT 126_ MDTYL 131_ GQFPD 136_ IKSRI 141_ AKRGR 146_ KLVDY 151_ DSARH 156_ HYESL 161_ QTAKK 166_ KDEAK 171_ IAKPV 176_ SLLEK 181_ AAPQW 186_ CQGKL 191_ QAHLV 196_ AQTNL 201_ LRNQA 206_ EEELI 211_ KAQKV 216_ FEEMN 221_ VDLQE 226_ ELPSL 231_ WNSRV 236_ GFYVN 241_ TFQSI 246_ AGLEE 251_ NFHKE 256_ MSKLN 261_ QNLND 266_ VLVGL 271_ EKQHG 276_ SNTFT 281_ VKAQP 286_ SDNAP 291_ AKGNK 296_ SPSPP 301_ DGSPA 306_ ATPEI 311_ RVNHE 316_ PEPAG 321_ GATPG 326_ ATLPK 331_ SPSQL 336_ RKGPP 341_ VPPPP 346_ KHTPS 351_ KEVKQ 356_ EQILS 361_ LFEDT 366_ FVPEI 371_ SVTTP 376_ SQFEA 381_ PGPFS 386_ EQASL 391_ LDLDF 396_ DPLPP 401_ VTSPV 406_ KAPTP 411_ SGQSI 416_ PWDLW 421_ EPTES 426_ PAGSL 431_ PSGEP 436_ SAAEG 441_ TFAVS 446_ WPSQT 451_ AEPGP 456_ AQPAE 461_ ASEVA 466_ GGTQP 471_ AAGAQ 476_ EPGET 481_ AASEA 486_ ASSSL 491_ PAVVV 496_ ETFPA 501_ TVNGT 506_ VEGGS 511_ GAGRL 516_ DLPPG 521_ FMFKV 526_ QAQHD 531_ YTATD 536_ TDELQ 541_ LKAGD 546_ VVLVI 551_ PFQNP 556_ EEQDE 561_ GWLMG 566_ VKESD 571_ WNQHK 576_ ELEKC 581_ RGVFP 586_ENFTE
1: Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863)