Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)
1_MAENP 6_ SLENH 11_ RIKSF 16_ KNKGR 21_ DVETM 26_ RRHRN 31_ EVTVE 36_ LRKNK 41_ RDEHL 46_ LKKRN 51_ VPQEE 56_ SLEDS 61_ DVDAD 66_ FKAQN 71_ VTLEA 76_ ILQNA 81_ TSDNP 86_ VVQLS 91_ AVQAA 96_ RKLLS 101_ SDRNP 106_ PIDDL 111_ IKSGI 116_ LPILV 121_ KCLER 126_ DDNPS 131_ LQFEA 136_ AWALT 141_ NIASG 146_ TSAQT 151_ QAVVQ 156_ SNAVP 161_ LFLRL 166_ LRSPH 171_ QNVCE 176_ QAVWA 181_ LGNII 186_ GDGPQ 191_ CRDYV 196_ ISLGV 201_ VKPLL 206_ SFISP 211_ SIPIT 216_ FLRNV 221_ TWVIV 226_ NLCRN 231_ KDPPP 236_ PMETV 241_ QEILP 246_ ALCVL 251_ IYHTD 256_ INILV 261_ DTVWA 266_ LSYLT 271_ DGGNE 276_ QIQMV 281_ IDSGV 286_ VPFLV 291_ PLLSH 296_ QEVKV 301_ QTAAL 306_ RAVGN 311_ IVTGT 316_ DEQTQ 321_ VVLNC 326_ DVLSH 331_ FPNLL 336_ SHPKE 341_ KINKE 346_ AVWFL 351_ SNITA 356_ GNQQQ 361_ VQAVI 366_ DAGLI 371_ PMIIH 376_ QLAKG 381_ DFGTQ 386_ KEAAW 391_ AISNL 396_ TISGR 401_ KDQVE 406_ YLVQQ 411_ NVIPP 416_ FCNLL 421_ SVKDS 426_ QVVQV 431_ VLDGL 436_ KNILI 441_ MAGDE 446_ ASTIA 451_ EIIEE 456_ CGGLE 461_ KIEVL 466_ QQHEN 471_ EDIYK 476_ LAFEI 481_ IDQYF 486_ SGDDI 491_ DEDPC 496_ LIPEA 501_ TQGGT 506_ YNFDP 511_ TANLQ 516_TKEFN
1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9