Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)
1_MAHLR 6_ GFANQ 11_ HSRVD 16_ PEELF 21_ TKLDR 26_ IGKGS 31_ FGEVY 36_ KGIDN 41_ HTKEV 46_ VAIKI 51_ IDLEE 56_ AEDEI 61_ EDIQQ 66_ EITVL 71_ SQCDS 76_ PYITR 81_ YFGSY 86_ LKSTK 91_ LWIIM 96_ EYLGG 101_ GSALD 106_ LLKPG 111_ PLEET 116_ YIATI 121_ LREIL 126_ KGLDY 131_ LHSER 136_ KIHRD 141_ IKAAN 146_ VLLSE 151_ QGDVK 156_ LADFG 161_ VAGQL 166_ TDTQI 171_ KRNTF 176_ VGTPF 181_ WMAPE 186_ VIKQS 191_ AYDFK 196_ ADIWS 201_ LGITA 206_ IELAK 211_ GEPPN 216_ SDLHP 221_ MRVLF 226_ LIPKN 231_ SPPTL 236_ EGQHS 241_ KPFKE 246_ FVEAC 251_ LNKDP 256_ RFRPT 261_ AKELL 266_ KHKFI 271_ TRYTK 276_ KTSFL 281_ TELID 286_ RYKRW 291_ KSEGH 296_ GEESS 301_ SEDSD 306_ IDGEA 311_ EDGEQ 316_ GPIWT 321_ FPPTI 326_ RPSPH 331_ SKLHK 336_ GTALH 341_ SSQKP 346_ AEPVK 351_ RQPRS 356_ QCLST 361_ LVRPV 366_ FGELK 371_ EKHKQ 376_ SGGSV 381_ GALEE 386_ LENAF 391_ SLAEE 396_ SCPGI 401_ SDKLM 406_ VHLVE 411_ RVQRF 416_ SHNRN 421_HLTST
1: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)