Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1)
1_MVQYE 6_ LWAAL 11_ PGASG 16_ VALAC 21_ CFVAA 26_ AVALR 31_ WSGRR 36_ TARGA 41_ VVRAR 46_ QRQRA 51_ GLENM 56_ DRAAQ 61_ RFRLQ 66_ NPDLD 71_ SEALL 76_ ALPLP 81_ QLVQK 86_ LHSRE 91_ LAPEA 96_ VLFTY 101_ VGKAW 106_ EVNKG 111_ TNCVT 116_ SYLAD 121_ CETQL 126_ SQAPR 131_ QGLLY 136_ GVPVS 141_ LKECF 146_ TYKGQ 151_ DSTLG 156_ LSLNE 161_ GVPAE 166_ CDSVV 171_ VHVLK 176_ LQGAV 181_ PFVHT 186_ NVPQS 191_ MFSYD 196_ CSNPL 201_ FGQTV 206_ NPWKS 211_ SKSPG 216_ GSSGG 221_ EGALI 226_ GSGGS 231_ PLGLG 236_ TDIGG 241_ SIRFP 246_ SSFCG 251_ ICGLK 256_ PTGNR 261_ LSKSG 266_ LKGCV 271_ YGQEA 276_ VRLSV 281_ GPMAR 286_ DVESL 291_ ALCLR 296_ ALLCE 301_ DMFRL 306_ DPTVP 311_ PLPFR 316_ EEVYT 321_ SSQPL 326_ RVGYY 331_ ETDNY 336_ TMPSP 341_ AMRRA 346_ VLETK 351_ QSLEA 356_ AGHTL 361_ VPFLP 366_ SNIPH 371_ ALETL 376_ STGGL 381_ FSDGG 386_ HTFLQ 391_ NFKGD 396_ FVDPC 401_ LGDLV 406_ SILKL 411_ PQWLK 416_ GLLAF 421_ LVKPL 426_ LPRLS 431_ AFLSN 436_ MKSRS 441_ AGKLW 446_ ELQHE 451_ IEVYR 456_ KTVIA 461_ QWRAL 466_ DLDVV 471_ LTPML 476_ APALD 481_ LNAPG 486_ RATGA 491_ VSYTM 496_ LYNCL 501_ DFPAG 506_ VVPVT 511_ TVTAE 516_ DEAQM 521_ EHYRG 526_ YFGDI 531_ WDKML 536_ QKGMK 541_ KSVGL 546_ PVAVQ 551_ CVALP 556_ WQEEL 561_ CLRFM 566_ REVER 571_LMTPE
1: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788, PubMed:9122178). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:17015445, PubMed:9122178). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity)