Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)
1_MGNPE 6_ NIEDA 11_ YVAVI 16_ RPKNT 21_ ASLNS 26_ REYRA 31_ KSYEI 36_ LLHEV 41_ PIEGQ 46_ KKKRK 51_ KVLLE 56_ TKLQG 61_ NSEIT 66_ QGILD 71_ YVVET 76_ TKPIS 81_ PANQG 86_ IRGKR 91_ VVLMK 96_ KFPLD 101_ GEKMG 106_ REASL 111_ FIVPS 116_ VVKDN 121_ TKYTY 126_ TPGCP 131_ IFYCL 136_ QDIMR 141_ VCSES 146_ STHFA 151_ TLTAR 156_ MLIAL 161_ DKWLD 166_ ERHAQ 171_ SHFIP 176_ ALFRP 181_ SPLER 186_ IKTNV 191_ INPAY 196_ ATESG 201_ QTENS 206_ LHMGY 211_ SALEI 216_ KSKML 221_ ALEKA 226_ DTCIY 231_ NPLFG 236_ SDLQY 241_ TNRVD 246_ KVVIN 251_ PYFGL 256_ GAPDY 261_ SKIQI 266_ PKQEK 271_ WQRSM 276_ SSVTE 281_ DKERQ 286_ WVDDF 291_ PLHRS 296_ ACEGD 301_ SELLS 306_ RLLSE 311_ RFSVN 316_ QLDSD 321_ HWAPI 326_ HYACW 331_ YGKVE 336_ ATRIL 341_ LEKGK 346_ CNPNL 351_ LNGQL 356_ SSPLH 361_ FAAGG 366_ GHAEI 371_ VQILL 376_ NHPET 381_ DRHIT 386_ DQQGR 391_ SPLNI 396_ CEENK 401_ QNNWE 406_ EAAKL 411_ LKEAI 416_ NKPYE 421_ KVRIY 426_ RMDGS 431_ YRSVE 436_ LKHGN 441_ NTTVQ 446_ QIMEG 451_ MRLSQ 456_ ETQQY 461_ FTIWI 466_ CSENL 471_ SLQLK 476_ PYHKP 481_ LQHVR 486_ DWPEI 491_ LAELT 496_ NLDPQ 501_ RETPQ 506_ LFLRR 511_ DVRLP 516_ LEVEK 521_ QIEDP 526_ LAILI 531_ LFDEA 536_ RYNLL 541_ KGFYT 546_ APDAK 551_ LITLA 556_ SLLLQ 561_ IVYGN 566_ YESKK 571_ HKQGF 576_ LNEEN 581_ LKSIV 586_ PVTKL 591_ KSKAP 596_ HWTNR 601_ ILHEY 606_ KNLST 611_ SEGVS 616_ KEMHH 621_ LQRMF 626_ LQNCW 631_ EIPTY 636_ GAAFF 641_ TGQIF 646_ TKASP 651_ SNHKV 656_ IPVYV 661_ GVNIK 666_ GLHLL 671_ NMETK 676_ ALLIS 681_ LKYGC 686_ FMWQL 691_ GDTDT 696_ CFQIH 701_ SMENK 706_ MSFIV 711_ HTKQA 716_ GLVVK 721_ LLMKL 726_ NGQLM 731_PTERN
1: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067)