Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)
1_MARFG 6_ DEMPA 11_ RYGGG 16_ GSGAA 21_ AGVVV 26_ GSGGG 31_ RGAGG 36_ SRQGG 41_ QPGAQ 46_ RMYKQ 51_ SMAQR 56_ ARTMA 61_ LYNPI 66_ PVRQN 71_ CLTVN 76_ RSLFL 81_ FSEDN 86_ VVRKY 91_ AKKIT 96_ EWPPF 101_ EYMIL 106_ ATIIA 111_ NCIVL 116_ ALEQH 121_ LPDDD 126_ KTPMS 131_ ERLDD 136_ TEPYF 141_ IGIFC 146_ FEAGI 151_ KIIAL 156_ GFAFH 161_ KGSYL 166_ RNGWN 171_ VMDFV 176_ VVLTG 181_ ILATV 186_ GTEFD 191_ LRTLR 196_ AVRVL 201_ RPLKL 206_ VSGIP 211_ SLQVV 216_ LKSIM 221_ KAMIP 226_ LLQIG 231_ LLLFF 236_ AILIF 241_ AIIGL 246_ EFYMG 251_ KFHTT 256_ CFEEG 261_ TDDIQ 266_ GESPA 271_ PCGTE 276_ EPART 281_ CPNGT 286_ KCQPY 291_ WEGPN 296_ NGITQ 301_ FDNIL 306_ FAVLT 311_ VFQCI 316_ TMEGW 321_ TDLLY 326_ NSNDA 331_ SGNTW 336_ NWLYF 341_ IPLII 346_ IGSFF 351_ MLNLV 356_ LGVLS 361_ GEFAK 366_ ERERV 371_ ENRRA 376_ FLKLR 381_ RQQQI 386_ ERELN 391_ GYMEW 396_ ISKAE 401_ EVILA 406_ EDETD 411_ GEQRH 416_ PFDAL 421_ RRTTI 426_ KKSKT 431_ DLLNP 436_ EEAED 441_ QLADI 446_ ASVGS 451_ PFARA 456_ SIKSA 461_ KLENS 466_ TFFHK 471_ KERRM 476_ RFYIR 481_ RMVKT 486_ QAFYW 491_ TVLSL 496_ VALNT 501_ LCVAI 506_ VHYNQ 511_ PEWLS 516_ DFLYY 521_ AEFIF 526_ LGLFM 531_ SEMFI 536_ KMYGL 541_ GTRPY 546_ FHSSF 551_ NCFDC 556_ GVIIG 561_ SIFEV 566_ IWAVI 571_ KPGTS 576_ FGISV 581_ LRALR 586_ LLRIF 591_ KVTKY 596_ WASLR 601_ NLVVS 606_ LLNSM 611_ KSIIS 616_ LLFLL 621_ FLFIV 626_ VFALL 631_ GMQLF 636_ GGQFN 641_ FDEGT 646_ PPTNF 651_ DTFPA 656_ AIMTV 661_ FQILT 666_ GEDWN 671_ EVMYD 676_ GIKSQ 681_ GGVQG 686_ GMVFS 691_ IYFIV 696_ LTLFG 701_ NYTLL 706_ NVFLA 711_ IAVDN 716_ LANAQ 721_ ELTKD 726_ EQEEE 731_ EAANQ 736_ KLALQ 741_ KAKEV 746_ AEVSP 751_ LSAAN 756_ MSIAV 761_ KEQQK 766_ NQKPA 771_ KSVWE 776_ QRTSE 781_ MRKQN 786_ LLASR 791_ EALYN 796_ EMDPD 801_ ERWKA 806_ AYTRH 811_ LRPDM 816_ KTHLD 821_ RPLVV 826_ DPQEN 831_ RNNNT 836_ NKSRA 841_ AEPTV 846_ DQRLG 851_ QQRAE 856_ DFLRK 861_ QARYH 866_ DRARD 871_ PSGSA 876_ GLDAR 881_ RPWAG 886_ SQEAE 891_ LSREG 896_ PYGRE 901_ SDHHA 906_ REGSL 911_ EQPGF 916_ WEGEA 921_ ERGKA 926_ GDPHR 931_ RHVHR 936_ QGGSR 941_ ESRSG 946_ SPRTG 951_ ADGEH 956_ RRHRA 961_ HRRPG 966_ EEGPE 971_ DKAER 976_ RARHR 981_ EGSRP 986_ ARGGE 991_ GEGEG 996_ PDGGE 1001_ RRRRH 1006_ RHGAP 1011_ ATYEG 1016_ DARRE 1021_ DKERR 1026_ HRRRK 1031_ ENQGS 1036_ GVPVS 1041_ GPNLS 1046_ TTRPI 1051_ QQDLG 1056_ RQDPP 1061_ LAEDI 1066_ DNMKN 1071_ NKLAT 1076_ AESAA 1081_ PHGSL 1086_ GHAGL 1091_ PQSPA 1096_ KMGNS 1101_ TDPGP 1106_ MLAIP 1111_ AMATN 1116_ PQNAA 1121_ SRRTP 1126_ NNPGN 1131_ PSNPG 1136_ PPKTP 1141_ ENSLI 1146_ VTNPS 1151_ GTQTN 1156_ SAKTA 1161_ RKPDH 1166_ TTVDI 1171_ PPACP 1176_ PPLNH 1181_ TVVQV 1186_ NKNAN 1191_ PDPLP 1196_ KKEEE 1201_ KKEEE 1206_ EDDRG 1211_ EDGPK 1216_ PMPPY 1221_ SSMFI 1226_ LSTTN 1231_ PLRRL 1236_ CHYIL 1241_ NLRYF 1246_ EMCIL 1251_ MVIAM 1256_ SSIAL 1261_ AAEDP 1266_ VQPNA 1271_ PRNNV 1276_ LRYFD 1281_ YVFTG 1286_ VFTFE 1291_ MVIKM 1296_ IDLGL 1301_ VLHQG 1306_ AYFRD 1311_ LWNIL 1316_ DFIVV 1321_ SGALV 1326_ AFAFT 1331_ GNSKG 1336_ KDINT 1341_ IKSLR 1346_ VLRVL 1351_ RPLKT 1356_ IKRLP 1361_ KLKAV 1366_ FDCVV 1371_ NSLKN 1376_ VFNIL 1381_ IVYML 1386_ FMFIF 1391_ AVVAV 1396_ QLFKG 1401_ KFFHC 1406_ TDESK 1411_ EFEKD 1416_ CRGKY 1421_ LLYEK 1426_ NEVKA 1431_ RDREW 1436_ KKYEF 1441_ HYDNV 1446_ LWALL 1451_ TLFTV 1456_ STGEG 1461_ WPQVL 1466_ KHSVD 1471_ ATFEN 1476_ QGPSP 1481_ GYRME 1486_ MSIFY 1491_ VVYFV 1496_ VFPFF 1501_ FVNIF 1506_ VALII 1511_ ITFQE 1516_ QGDKM 1521_ MEEYS 1526_ LEKNE 1531_ RACID 1536_ FAISA 1541_ KPLTR 1546_ HMPQN 1551_ KQSFQ 1556_ YRMWQ 1561_ FVVSP 1566_ PFEYT 1571_ IMAMI 1576_ ALNTI 1581_ VLMMK 1586_ FYGAS 1591_ VAYEN 1596_ ALRVF 1601_ NIVFT 1606_ SLFSL 1611_ ECVLK 1616_ VMAFG 1621_ ILNYF 1626_ RDAWN 1631_ IFDFV 1636_ TVLGS 1641_ ITDIL 1646_ VTEFG 1651_ NNFIN 1656_ LSFLR 1661_ LFRAA 1666_ RLIKL 1671_ LRQGY 1676_ TIRIL 1681_ LWTFV 1686_ QSFKA 1691_ LPYVC 1696_ LLIAM 1701_ LFFIY 1706_ AIIGM 1711_ QVFGN 1716_ IGIDV 1721_ EDEDS 1726_ DEDEF 1731_ QITEH 1736_ NNFRT 1741_ FFQAL 1746_ MLLFR 1751_ SATGE 1756_ AWHNI 1761_ MLSCL 1766_ SGKPC 1771_ DKNSG 1776_ ILTRE 1781_ CGNEF 1786_ AYFYF 1791_ VSFIF 1796_ LCSFL 1801_ MLNLF 1806_ VAVIM 1811_ DNFEY 1816_ LTRDS 1821_ SILGP 1826_ HHLDE 1831_ YVRVW 1836_ AEYDP 1841_ AAWGR 1846_ MPYLD 1851_ MYQML 1856_ RHMSP 1861_ PLGLG 1866_ KKCPA 1871_ RVAYK 1876_ RLLRM 1881_ DLPVA 1886_ DDNTV 1891_ HFNST 1896_ LMALI 1901_ RTALD 1906_ IKIAK 1911_ GGADK 1916_ QQMDA 1921_ ELRKE 1926_ MMAIW 1931_ PNLSQ 1936_ KTLDL 1941_ LVTPH 1946_ KSTDL 1951_ TVGKI 1956_ YAAMM 1961_ IMEYY 1966_ RQSKA 1971_ KKLQA 1976_ MREEQ 1981_ DRTPL 1986_ MFQRM 1991_ EPPSP 1996_ TQEGG 2001_ PGQNA 2006_ LPSTQ 2011_ LDPGG 2016_ ALMAH 2021_ ESGLK 2026_ ESPSW 2031_ VTQRA 2036_ QEMFQ 2041_ KTGTW 2046_ SPEQG 2051_ PPTDM 2056_ PNSQP 2061_ NSQSV 2066_ EMREM 2071_ GRDGY 2076_ SDSEH 2081_ YLPME 2086_ GQGRA 2091_ ASMPR 2096_ LPAEN 2101_ QRRRG 2106_ RPRGN 2111_ NLSTI 2116_ SDTSP 2121_ MKRSA 2126_ SVLGP 2131_ KARRL 2136_ DDYSL 2141_ ERVPP 2146_ EENQR 2151_ HHQRR 2156_ RDRSH 2161_ RASER 2166_ SLGRY 2171_ TDVDT 2176_ GLGTD 2181_ LSMTT 2186_ QSGDL 2191_ PSKER 2196_ DQERG 2201_ RPKDR 2206_ KHRQH 2211_ HHHHH 2216_ HHHHP 2221_ PPPDK 2226_ DRYAQ 2231_ ERPDH 2236_ GRARA 2241_ RDQRW 2246_ SRSPS 2251_ EGREH 2256_ MAHRQ 2261_ GSSSV 2266_ SGSPA 2271_ PSTSG 2276_ TSTPR 2281_ RGRRQ 2286_ LPQTP 2291_ STPRP 2296_ HVSYS 2301_ PVIRK 2306_ AGGSG 2311_ PPQQQ 2316_ QQQQQ 2321_ QQQQQ 2326_ AVARP 2331_ GRAAT 2336_ SGPRR 2341_ YPGPT 2346_ AEPLA 2351_ GDRPP 2356_ TGGHS 2361_ SGRSP 2366_ RMERR 2371_ VPGPA 2376_ RSESP 2381_ RACRH 2386_ GGARW 2391_ PASGP 2396_ HVSEG 2401_ PPGPR 2406_ HHGYY 2411_ RGSDY 2416_ DEADG 2421_ PGSGG 2426_ GEEAM 2431_ AGAYD 2436_ APPPV 2441_ RHASS 2446_ GATGR 2451_ SPRTP 2456_ RASGP 2461_ ACASP 2466_ SRHGR 2471_ RLPNG 2476_ YYPAH 2481_ GLARP 2486_ RGPGS 2491_ RKGLH 2496_ EPYSE 2501_SDDDW
1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP)