Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)
1_MSLYP 6_ SLEDL 11_ KVDKV 16_ IQAQT 21_ AFSAN 26_ PANPA 31_ ILSEA 36_ SAPIP 41_ HDGNL 46_ YPRLY 51_ PELSQ 56_ YMGLS 61_ LNEEE 66_ IRANV 71_ AVVSG 76_ APLQG 81_ QLVAR 86_ PSSIN 91_ YMVAP 96_ VTGND 101_ VGIRR 106_ AEIKQ 111_ GIREV 116_ ILCKD 121_ QDGKI 126_ GLRLK 131_ SIDNG 136_ IFVQL 141_ VQANS 146_ PASLV 151_ GLRFG 156_ DQVLQ 161_ INGEN 166_ CAGWS 171_ SDKAH 176_ KVLKQ 181_ AFGEK 186_ ITMTI 191_ RDRPF 196_ ERTIT 201_ MHKDS 206_ TGHVG 211_ FIFKN 216_ GKITS 221_ IVKDS 226_ SAARN 231_ GLLTE 236_ HNICE 241_ INGQN 246_ VIGLK 251_ DSQIA 256_ DILST 261_ SGTVV 266_ TITIM 271_ PAFIF 276_ EHIIK 281_ RMAPS 286_ IMKSL 291_MDHTI
1: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395)