Nucleolar protein 56 (Nucleolar protein 5A)
1_MVLLH 6_ VLFEH 11_ AVGYA 16_ LLALK 21_ EVEEI 26_ SLLQP 31_ QVEES 36_ VLNLG 41_ KFHSI 46_ VRLVA 51_ FCPFA 56_ SSQVA 61_ LENAN 66_ AVSEG 71_ VVHED 76_ LRLLL 81_ ETHLP 86_ SKKKK 91_ VLLGV 96_ GDPKI 101_ GAAIQ 106_ EELGY 111_ NCQTG 116_ GVIAE 121_ ILRGV 126_ RLHFH 131_ NLVKG 136_ LTDLS 141_ ACKAQ 146_ LGLGH 151_ SYSRA 156_ KVKFN 161_ VNRVD 166_ NMIIQ 171_ SISLL 176_ DQLDK 181_ DINTF 186_ SMRVR 191_ EWYGY 196_ HFPEL 201_ VKIIN 206_ DNATY 211_ CRLAQ 216_ FIGNR 221_ RELNE 226_ DKLEK 231_ LEELT 236_ MDGAK 241_ AKAIL 246_ DASRS 251_ SMGMD 256_ ISAID 261_ LINIE 266_ SFSSR 271_ VVSLS 276_ EYRQS 281_ LHTYL 286_ RSKMS 291_ QVAPS 296_ LSALI 301_ GEAVG 306_ ARLIA 311_ HAGSL 316_ TNLAK 321_ YPAST 326_ VQILG 331_ AEKAL 336_ FRALK 341_ TRGNT 346_ PKYGL 351_ IFHST 356_ FIGRA 361_ AAKNK 366_ GRISR 371_ YLANK 376_ CSIAS 381_ RIDCF 386_ SEVPT 391_ SVFGE 396_ KLREQ 401_ VEERL 406_ SFYET 411_ GEIPR 416_ KNLDV 421_ MKEAM 426_ VQAEE 431_ AAAEI 436_ TRKLE 441_ KQEKK 446_ RLKKE 451_ KKRLA 456_ ALALA 461_ SSENS 466_ SSTPE 471_ ECEEM 476_ SEKPK 481_ KKKKQ 486_ KPQEV 491_ PQENG 496_ MEDPS 501_ ISFSK 506_ PKKKK 511_ SFSKE 516_ ELMSS 521_ DLEET 526_ AGSTS 531_ IPKRK 536_ KSTPK 541_ EETVN 546_ DPEEA 551_ GHRSG 556_ SKKKR 561_ KFSKE 566_ EPVSS 571_ GPEEA 576_ VGKSS 581_ SKKKK 586_KFHKA
1: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315)