Ribonuclease T2 (EC 4.6.1.19) (Ribonuclease 6)
1_MRPAA 6_ LRGAL 11_ LGCLC 16_ LALLC 21_ LGGAD 26_ KRLRD 31_ NHEWK 36_ KLIMV 41_ QHWPE 46_ TVCEK 51_ IQNDC 56_ RDPPD 61_ YWTIH 66_ GLWPD 71_ KSEGC 76_ NRSWP 81_ FNLEE 86_ IKDLL 91_ PEMRA 96_ YWPDV 101_ IHSFP 106_ NRSRF 111_ WKHEW 116_ EKHGT 121_ CAAQV 126_ DALNS 131_ QKKYF 136_ GRSLE 141_ LYREL 146_ DLNSV 151_ LLKLG 156_ IKPSI 161_ NYYQV 166_ ADFKD 171_ ALARV 176_ YGVIP 181_ KIQCL 186_ PPSQD 191_ EEVQT 196_ IGQIE 201_ LCLTK 206_ QDQQL 211_ QNCTE 216_ PGEQP 221_ SPKQE 226_ VWLAN 231_ GAAES 236_ RGLRV 241_ CEDGP 246_ VFYPP 251_PKKTK
1: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed:31778653). Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides (PubMed:31778653, PubMed:38697119). In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed:31778653). In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7 (PubMed:38697119). Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed:28730546, PubMed:30184494). Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed:30385512)