C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21)
1_MAQSL 6_ ALSLL 11_ ILVLA 16_ FGIPR 21_ TQGSD 26_ GGAQD 31_ CCLKY 36_ SQRKI 41_ PAKVV 46_ RSYRK 51_ QEPSL 56_ GCSIP 61_ AILFL 66_ PRKRS 71_ QAELC 76_ ADPKE 81_ LWVQQ 86_ LMQHL 91_ DKTPS 96_ PQKPA 101_ QGCRK 106_ DRGAS 111_ KTGKK 116_ GKGSK 121_ GCKRT 126_ERSQT
1: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4