Beta-1,3-N-acetylglucosaminyltransferase manic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
1_MQCRL 6_ PRGLA 11_ GALLT 16_ LLCMG 21_ LLCLR 26_ YHLNL 31_ SPQRV 36_ QGTPE 41_ LSQPN 46_ PGPPK 51_ LQLHD 56_ VFIAV 61_ KTTRA 66_ FHRLR 71_ LELLL 76_ DTWVS 81_ RTREQ 86_ TFVFT 91_ DSPDK 96_ GLQER 101_ LGSHL 106_ VVTNC 111_ SAEHS 116_ HPALS 121_ CKMAA 126_ EFDTF 131_ LASGL 136_ RWFCH 141_ VDDDN 146_ YVNPR 151_ ALLQL 156_ LRAFP 161_ LARDV 166_ YVGRP 171_ SLNRP 176_ IHASE 181_ PQPHN 186_ RTRLV 191_ QFWFA 196_ TGGAG 201_ FCINR 206_ KLALK 211_ MAPWA 216_ SGSRF 221_ MDTSA 226_ LIRLP 231_ DDCTM 236_ GYIIE 241_ CKLGG 246_ RLQPS 251_ PLFHS 256_ HLETL 261_ QLLRT 266_ AQLPE 271_ QVTLS 276_ YGVFE 281_ GKLNV 286_ IKLQG 291_ PFSPE 296_ EDPSR 301_ FRSLH 306_ CLLYP 311_ DTPWC 316_PQLGA
1: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity)