Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi)
1_MNYSL 6_ HLAFV 11_ CLSLF 16_ TERMC 21_ IQGSQ 26_ FNVEV 31_ GRSDK 36_ LSLPG 41_ FENLT 46_ AGYNK 51_ FLRPN 56_ FGGEP 61_ VQIAL 66_ TLDIA 71_ SISSI 76_ SESNM 81_ DYTAT 86_ IYLRQ 91_ RWMDQ 96_ RLVFE 101_ GNKSF 106_ TLDAR 111_ LVEFL 116_ WVPDT 121_ YIVES 126_ KKSFL 131_ HEVTV 136_ GNRLI 141_ RLFSN 146_ GTVLY 151_ ALRIT 156_ TTVAC 161_ NMDLS 166_ KYPMD 171_ TQTCK 176_ LQLES 181_ WGYDG 186_ NDVEF 191_ TWLRG 196_ NDSVR 201_ GLEHL 206_ RLAQY 211_ TIERY 216_ FTLVT 221_ RSQQE 226_ TGNYT 231_ RLVLQ 236_ FELRR 241_ NVLYF 246_ ILETY 251_ VPSTF 256_ LVVLS 261_ WVSFW 266_ ISLDS 271_ VPART 276_ CIGVT 281_ TVLSM 286_ TTLMI 291_ GSRTS 296_ LPNTN 301_ CFIKA 306_ IDVYL 311_ GICFS 316_ FVFGA 321_ LLEYA 326_ VAHYS 331_ SLQQM 336_ AAKDR 341_ GTTKE 346_ VEEVS 351_ ITNII 356_ NSSIS 361_ SFKRK 366_ ISFAS 371_ IEISS 376_ DNVDY 381_ SDLTM 386_ KTSDK 391_ FKFVF 396_ REKMG 401_ RIVDY 406_ FTIQN 411_ PSNVD 416_ HYSKL 421_ LFPLI 426_ FMLAN 431_VFYWA
1: Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548). Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (PubMed:9182563). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (By similarity)