Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
1_MRCAL 6_ ALSAL 11_ LLLLS 16_ TPPLL 21_ PSSPS 26_ PSPSP 31_ SQNAT 36_ QTTTD 41_ SSNKT 46_ APTPA 51_ SSVTI 56_ MATDT 61_ AQQST 66_ VPTSK 71_ ANEIL 76_ ASVKA 81_ TTLGV 86_ SSDSP 91_ GTTTL 96_ AQQVS 101_ GPVNT 106_ TVARG 111_ GGSGN 116_ PTTTI 121_ ESPKS 126_ TKSAD 131_ TTTVA 136_ TSTAT 141_ AKPNT 146_ TSSQN 151_ GAEDT 156_ TNSGG 161_ KSSHS 166_ VTTDL 171_ TSTKA 176_ EHLTT 181_ PHPTS 186_ PLSPR 191_ QPTST 196_ HPVAT 201_ PTSSG 206_ HDHLM 211_ KISSS 216_ SSTVA 221_ IPGYT 226_ FTSPG 231_ MTTTL 236_ LETVF 241_ HHVSQ 246_ AGLEL 251_ LTSGD 256_ LPTLA 261_ SQSAG 266_ ITASS 271_ VISQR 276_ TQQTS 281_ SQMPA 286_ SSTAP 291_ SSQET 296_ VQPTS 301_ PATAL 306_ RTPTL 311_ PETMS 316_ SSPTA 321_ ASTTH 326_ RYPKT 331_ PSPTV 336_ AHESN 341_ WAKCE 346_ DLETQ 351_ TQSEK 356_ QLVLN 361_ LTGNT 366_ LCAGG 371_ ASDEK 376_ LISLI 381_ CRAVK 386_ ATFNP 391_ AQDKC 396_ GIRLA 401_ SVPGS 406_ QTVVV 411_ KEITI 416_ HTKLP 421_ AKDVY 426_ ERLKD 431_ KWDEL 436_ KEAGV 441_ SDMKL 446_ GDQGP 451_ PEEAE 456_ DRFSM 461_ PLIIT 466_ IVCMA 471_ SFLLL 476_ VAALY 481_ GCCHQ 486_ RLSQR 491_ KDQQR 496_ LTEEL 501_ QTVEN 506_ GYHDN 511_ PTLEV 516_ METSS 521_ EMQEK 526_ KVVSL 531_ NGELG 536_ DSWIV 541_ PLDNL 546_ TKDDL 551_DEEED
1: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells