Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)
1_MELSG 6_ ATMAR 11_ GLAVL 16_ LVLFL 21_ HIKNL 26_ PAQAA 31_ DTCPE 36_ VKVVG 41_ LEGSD 46_ KLTIL 51_ RGCPG 56_ LPGAP 61_ GPKGE 66_ AGVIG 71_ ERGER 76_ GLPGA 81_ PGKAG 86_ PVGPK 91_ GDRGE 96_ KGMRG 101_ EKGDA 106_ GQSQS 111_ CATGP 116_ RNCKD 121_ LLDRG 126_ YFLSG 131_ WHTIY 136_ LPDCR 141_ PLTVL 146_ CDMDT 151_ DGGGW 156_ TVFQR 161_ RMDGS 166_ VDFYR 171_ DWAAY 176_ KQGFG 181_ SQLGE 186_ FWLGN 191_ DNIHA 196_ LTAQG 201_ SSELR 206_ VDLVD 211_ FEGNH 216_ QFAKY 221_ KSFKV 226_ ADEAE 231_ KYKLV 236_ LGAFV 241_ GGSAG 246_ NSLTG 251_ HNNNF 256_ FSTKD 261_ QDNDV 266_ SSSNC 271_ AEKFQ 276_ GAWWY 281_ ADCHA 286_ SNLNG 291_ LYLMG 296_ PHESY 301_ ANGIN 306_ WSAAK 311_ GYKYS 316_ YKVSE 321_MKVRP
1: Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage