CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1)
1_MSSRI 6_ ARALA 11_ LVVTL 16_ LHLTR 21_ LALST 26_ CPAAC 31_ HCPLE 36_ APKCA 41_ PGVGL 46_ VRDGC 51_ GCCKV 56_ CAKQL 61_ NEDCS 66_ KTQPC 71_ DHTKG 76_ LECNF 81_ GASST 86_ ALKGI 91_ CRAQS 96_ EGRPC 101_ EYNSR 106_ IYQNG 111_ ESFQP 116_ NCKHQ 121_ CTCID 126_ GAVGC 131_ IPLCP 136_ QELSL 141_ PNLGC 146_ PNPRL 151_ VKVTG 156_ QCCEE 161_ WVCDE 166_ DSIKD 171_ PMEDQ 176_ DGLLG 181_ KELGF 186_ DASEV 191_ ELTRN 196_ NELIA 201_ VGKGS 206_ SLKRL 211_ PVFGM 216_ EPRIL 221_ YNPLQ 226_ GQKCI 231_ VQTTS 236_ WSQCS 241_ KTCGT 246_ GISTR 251_ VTNDN 256_ PECRL 261_ VKETR 266_ ICEVR 271_ PCGQP 276_ VYSSL 281_ KKGKK 286_ CSKTK 291_ KSPEP 296_ VRFTY 301_ AGCLS 306_ VKKYR 311_ PKYCG 316_ SCVDG 321_ RCCTP 326_ QLTRT 331_ VKMRF 336_ RCEDG 341_ ETFSK 346_ NVMMI 351_ QSCKC 356_ NYNCP 361_ HANEA 366_ AFPFY 371_ RLFND 376_IHKFR
1: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3