Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3)
1_MAEHG 6_ AHFTA 11_ ASVAD 16_ DQPSI 21_ FEVVA 26_ QDSLM 31_ TAVRP 36_ ALQHV 41_ VKVLA 46_ ESNPT 51_ HYGFL 56_ WRWFD 61_ EIFTL 66_ LDLLL 71_ QQHYL 76_ SRTSA 81_ SFSEN 86_ FYGLK 91_ RIVMG 96_ DTHKS 101_ QRLAS 106_ AGLPK 111_ QQLWK 116_ SIMFL 121_ VLLPY 126_ LKVKL 131_ EKLVS 136_ SLREE 141_ DEYSI 146_ HPPSS 151_ RWKRF 156_ YRAFL 161_ AAYPF 166_ VNMAW 171_ EGWFL 176_ VQQLR 181_ YILGK 186_ AQHHS 191_ PLLRL 196_ AGVQL 201_ GRLTV 206_ QDIQA 211_ LEHKP 216_ AKASM 221_ MQQPA 226_ RSVSE 231_ KINSA 236_ LKKAV 241_ GGVAL 246_ SLSTG 251_ LSVGV 256_ FFLQF 261_ LDWWY 266_ SSENQ 271_ ETIKS 276_ LTALP 281_ TPPPP 286_ VHLDY 291_ NSDSP 296_ LLPKM 301_ KTVCP 306_ LCRKT 311_ RVNDT 316_ VLATS 321_ GYVFC 326_ YRCVF 331_ HYVRS 336_ HQACP 341_ ITGYP 346_ TEVQH 351_LIKLY
1: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292, PubMed:9354782, PubMed:9632816). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:24662292). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)