Gene name: PIR

Uniprot entry:

O00625

Protein names:

Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)

Protein sequence:

1_MGSSK 6_ KVTLS 11_ VLSRE 16_ QSEGV 21_ GARVR 26_ RSIGR 31_ PELKN 36_ LDPFL 41_ LFDEF 46_ KGGRP 51_ GGFPD 56_ HPHRG 61_ FETVS 66_ YLLEG 71_ GSMAH 76_ EDFCG 81_ HTGKM 86_ NPGDL 91_ QWMTA 96_ GRGIL 101_ HAEMP 106_ CSEEP 111_ AHGLQ 116_ LWVNL 121_ RSSEK 126_ MVEPQ 131_ YQELK 136_ SEEIP 141_ KPSKD 146_ GVTVA 151_ VISGE 156_ ALGIK 161_ SKVYT 166_ RTPTL 171_ YLDFK 176_ LDPGA 181_ KHSQP 186_ IPKGW 191_ TSFIY 196_ TISGD 201_ VYIGP 206_ DDAQQ 211_ KIEPH 216_ HTAVL 221_ GEGDS 226_ VQVEN 231_ KDPKR 236_ SHFVL 241_ IAGEP 246_ LREPV 251_ IQHGP 256_ FVMNT 261_ NEEIS 266_ QAILD 271_ FRNAK 276_ NGFER 281_AKTWK

Protein annotations

Protein functions:

1: Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro)