Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
1_MADNE 6_ KLDNQ 11_ RLKNF 16_ KNKGR 21_ DLETM 26_ RRQRN 31_ EVVVE 36_ LRKNK 41_ RDEHL 46_ LKRRN 51_ VPHED 56_ ICEDS 61_ DIDGD 66_ YRVQN 71_ TSLEA 76_ IVQNA 81_ SSDNQ 86_ GIQLS 91_ AVQAA 96_ RKLLS 101_ SDRNP 106_ PIDDL 111_ IKSGI 116_ LPILV 121_ HCLER 126_ DDNPS 131_ LQFEA 136_ AWALT 141_ NIASG 146_ TSEQT 151_ QAVVQ 156_ SNAVP 161_ LFLRL 166_ LHSPH 171_ QNVCE 176_ QAVWA 181_ LGNII 186_ GDGPQ 191_ CRDYV 196_ ISLGV 201_ VKPLL 206_ SFISP 211_ SIPIT 216_ FLRNV 221_ TWVMV 226_ NLCRH 231_ KDPPP 236_ PMETI 241_ QEILP 246_ ALCVL 251_ IHHTD 256_ VNILV 261_ DTVWA 266_ LSYLT 271_ DAGNE 276_ QIQMV 281_ IDSGI 286_ VPHLV 291_ PLLSH 296_ QEVKV 301_ QTAAL 306_ RAVGN 311_ IVTGT 316_ DEQTQ 321_ VVLNC 326_ DALSH 331_ FPALL 336_ THPKE 341_ KINKE 346_ AVWFL 351_ SNITA 356_ GNQQQ 361_ VQAVI 366_ DANLV 371_ PMIIH 376_ LLDKG 381_ DFGTQ 386_ KEAAW 391_ AISNL 396_ TISGR 401_ KDQVA 406_ YLIQQ 411_ NVIPP 416_ FCNLL 421_ TVKDA 426_ QVVQV 431_ VLDGL 436_ SNILK 441_ MAEDE 446_ AETIG 451_ NLIEE 456_ CGGLE 461_ KIEQL 466_ QNHEN 471_ EDIYK 476_ LAYEI 481_ IDQFF 486_ SSDDI 491_ DEDPS 496_ LVPEA 501_ IQGGT 506_ FGFNS 511_ SANVP 516_TEGFQ
1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Mediates nuclear import of AARS1, MRTFA and RANBP3 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:38512451)
2: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS