Gene name: SLN

Uniprot entry:

O00631

Protein names:

Sarcolipin

Protein sequence:

1_MGINT 6_ RELFL 11_ NFTIV 16_ LITVI 21_ LMWLL 26_VRSYQ

Protein annotations

Protein functions:

1: Reversibly inhibits the activity of ATP2A1/SERCA1 and ATP2A2/SERCA2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:11781085, PubMed:9575189). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity)