E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet)
1_MASTT 6_ STKKM 11_ MEEAT 16_ CSICL 21_ SLMTN 26_ PVSIN 31_ CGHSY 36_ CHLCI 41_ TDFFK 46_ NPSQK 51_ QLRQE 56_ TFCCP 61_ QCRAP 66_ FHMDS 71_ LRPNK 76_ QLGSL 81_ IEALK 86_ ETDQE 91_ MSCEE 96_ HGEQF 101_ HLFCE 106_ DEGQL 111_ ICWRC 116_ ERAPQ 121_ HKGHT 126_ TALVE 131_ DVCQG 136_ YKEKL 141_ QKAVT 146_ KLKQL 151_ EDRCT 156_ EQKLS 161_ TAMRI 166_ TKWKE 171_ KVQIQ 176_ RQKIR 181_ SDFKN 186_ LQCFL 191_ HEEEK 196_ SYLWR 201_ LEKEE 206_ QQTLS 211_ RLRDY 216_ EAGLG 221_ LKSNE 226_ LKSHI 231_ LELEE 236_ KCQGS 241_ AQKLL 246_ QNVND 251_ TLSRS 256_ WAVKL 261_ ETSEA 266_ VSLEL 271_ HTMCN 276_ VSKLY 281_ FDVKK 286_ MLRSH 291_ QVSVT 296_ LDPDT 301_ AHHEL 306_ ILSED 311_ RRQVT 316_ RGYTQ 321_ ENQDT 326_ SSRRF 331_ TAFPC 336_ VLGCE 341_ GFTSG 346_ RRYFE 351_ VDVGE 356_ GTGWD 361_ LGVCM 366_ ENVQR 371_ GTGMK 376_ QEPQS 381_ GFWTL 386_ RLCKK 391_ KGYVA 396_ LTSPP 401_ TSLHL 406_ HEQPL 411_ LVGIF 416_ LDYEA 421_ GVVSF 426_ YNGNT 431_ GCHIF 436_ TFPKA 441_ SFSDT 446_ LRPYF 451_ QVYQY 456_SPLFL
1: E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470). Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549)