Transcription factor E2F3 (E2F-3)
1_MRKGI 6_ QPALE 11_ QYLVT 16_ AGGGE 21_ GAAVV 26_ AAAAA 31_ ASMDK 36_ RALLA 41_ SPGFA 46_ AAAAA 51_ AAAPG 56_ AYIQI 61_ LTTNT 66_ STTSC 71_ SSSLQ 76_ SGAVA 81_ AGPLL 86_ PSAPG 91_ AEQTA 96_ GSLLY 101_ TTPHG 106_ PSSRA 111_ GLLQQ 116_ PPALG 121_ RGGSG 126_ GGGGP 131_ PAKRR 136_ LELGE 141_ SGHQY 146_ LSDGL 151_ KTPKG 156_ KGRAA 161_ LRSPD 166_ SPKTP 171_ KSPSE 176_ KTRYD 181_ TSLGL 186_ LTKKF 191_ IQLLS 196_ QSPDG 201_ VLDLN 206_ KAAEV 211_ LKVQK 216_ RRIYD 221_ ITNVL 226_ EGIHL 231_ IKKKS 236_ KNNVQ 241_ WMGCS 246_ LSEDG 251_ GMLAQ 256_ CQGLS 261_ KEVTE 266_ LSQEE 271_ KKLDE 276_ LIQSC 281_ TLDLK 286_ LLTED 291_ SENQR 296_ LAYVT 301_ YQDIR 306_ KISGL 311_ KDQTV 316_ IVVKA 321_ PPETR 326_ LEVPD 331_ SIESL 336_ QIHLA 341_ STQGP 346_ IEVYL 351_ CPEET 356_ ETHSP 361_ MKTNN 366_ QDHNG 371_ NIPKP 376_ ASKDL 381_ ASTNS 386_ GHSDC 391_ SVSMG 396_ NLSPL 401_ ASPAN 406_ LLQQT 411_ EDQIP 416_ SNLEG 421_ PFVNL 426_ LPPLL 431_ QEDYL 436_ LSLGE 441_ EEGIS 446_ DLFDA 451_ YDLEK 456_LPLVE
1: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity)