Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]
1_MAPLD 6_ LDKYV 11_ EIARL 16_ CKYLP 21_ ENDLK 26_ RLCDY 31_ VCDLL 36_ LEESN 41_ VQPVS 46_ TPVTV 51_ CGDIH 56_ GQFYD 61_ LCELF 66_ RTGGQ 71_ VPDTN 76_ YIFMG 81_ DFVDR 86_ GYYSL 91_ ETFTY 96_ LLALK 101_ AKWPD 106_ RITLL 111_ RGNHE 116_ SRQIT 121_ QVYGF 126_ YDECQ 131_ TKYGN 136_ ANAWR 141_ YCTKV 146_ FDMLT 151_ VAALI 156_ DEQIL 161_ CVHGG 166_ LSPDI 171_ KTLDQ 176_ IRTIE 181_ RNQEI 186_ PHKGA 191_ FCDLV 196_ WSDPE 201_ DVDTW 206_ AISPR 211_ GAGWL 216_ FGAKV 221_ TNEFV 226_ HINNL 231_ KLICR 236_ AHQLV 241_ HEGYK 246_ FMFDE 251_ KLVTV 256_ WSAPN 261_ YCYRC 266_ GNIAS 271_ IMVFK 276_ DVNTR 281_ EPKLF 286_ RAVPD 291_ SERVI 296_PPRTT
1: Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700, PubMed:32753499). CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700)