Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)
1_MRLHR 6_ LRARL 11_ SAVAC 16_ GLLLL 21_ LVRGQ 26_ GQDSA 31_ SPIRT 36_ THTGQ 41_ VLGSL 46_ VHVKG 51_ ANAGV 56_ QTFLG 61_ IPFAK 66_ PPLGP 71_ LRFAP 76_ PEPPE 81_ SWSGV 86_ RDGTT 91_ HPAMC 96_ LQDLT 101_ AVESE 106_ FLSQF 111_ NMTFP 116_ SDSMS 121_ EDCLY 126_ LSIYT 131_ PAHSH 136_ EGSNL 141_ PVMVW 146_ IHGGA 151_ LVFGM 156_ ASLYD 161_ GSMLA 166_ ALENV 171_ VVVII 176_ QYRLG 181_ VLGFF 186_ STGDK 191_ HATGN 196_ WGYLD 201_ QVAAL 206_ RWVQQ 211_ NIAHF 216_ GGNPD 221_ RVTIF 226_ GESAG 231_ GTSVS 236_ SLVVS 241_ PISQG 246_ LFHGA 251_ IMESG 256_ VALLP 261_ GLIAS 266_ SADVI 271_ STVVA 276_ NLSAC 281_ DQVDS 286_ EALVG 291_ CLRGK 296_ SKEEI 301_ LAINK 306_ PFKMI 311_ PGVVD 316_ GVFLP 321_ RHPQE 326_ LLASA 331_ DFQPV 336_ PSIVG 341_ VNNNE 346_ FGWLI 351_ PKVMR 356_ IYDTQ 361_ KEMDR 366_ EASQA 371_ ALQKM 376_ LTLLM 381_ LPPTF 386_ GDLLR 391_ EEYIG 396_ DNGDP 401_ QTLQA 406_ QFQEM 411_ MADSM 416_ FVIPA 421_ LQVAH 426_ FQCSR 431_ APVYF 436_ YEFQH 441_ QPSWL 446_ KNIRP 451_ PHMKA 456_ DHGDE 461_ LPFVF 466_ RSFFG 471_ GNYIK 476_ FTEEE 481_ EQLSR 486_ KMMKY 491_ WANFA 496_ RNGNP 501_ NGEGL 506_ PHWPL 511_ FDQEE 516_ QYLQL 521_ NLQPA 526_ VGRAL 531_ KAHRL 536_ QFWKK 541_ ALPQK 546_ IQELE 551_EPEER
1: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984)