Protein Wnt-7a
1_MNRKA 6_ RRCLG 11_ HLFLS 16_ LGMVY 21_ LRIGG 26_ FSSVV 31_ ALGAS 36_ IICNK 41_ IPGLA 46_ PRQRA 51_ ICQSR 56_ PDAII 61_ VIGEG 66_ SQMGL 71_ DECQF 76_ QFRNG 81_ RWNCS 86_ ALGER 91_ TVFGK 96_ ELKVG 101_ SREAA 106_ FTYAI 111_ IAAGV 116_ AHAIT 121_ AACTQ 126_ GNLSD 131_ CGCDK 136_ EKQGQ 141_ YHRDE 146_ GWKWG 151_ GCSAD 156_ IRYGI 161_ GFAKV 166_ FVDAR 171_ EIKQN 176_ ARTLM 181_ NLHNN 186_ EAGRK 191_ ILEEN 196_ MKLEC 201_ KCHGV 206_ SGSCT 211_ TKTCW 216_ TTLPQ 221_ FRELG 226_ YVLKD 231_ KYNEA 236_ VHVEP 241_ VRASR 246_ NKRPT 251_ FLKIK 256_ KPLSY 261_ RKPMD 266_ TDLVY 271_ IEKSP 276_ NYCEE 281_ DPVTG 286_ SVGTQ 291_ GRACN 296_ KTAPQ 301_ ASGCD 306_ LMCCG 311_ RGYNT 316_ HQYAR 321_ VWQCN 326_ CKFHW 331_ CCYVK 336_ CNTCS 341_ERTEM
1: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity)