Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
1_MASQN 6_ RDPAA 11_ TSVAA 16_ ARKGA 21_ EPSGG 26_ AARGP 31_ VGKRL 36_ QQELM 41_ TLMMS 46_ GDKGI 51_ SAFPE 56_ SDNLF 61_ KWVGT 66_ IHGAA 71_ GTVYE 76_ DLRYK 81_ LSLEF 86_ PSGYP 91_ YNAPT 96_ VKFLT 101_ PCYHP 106_ NVDTQ 111_ GNICL 116_ DILKE 121_ KWSAL 126_ YDVRT 131_ ILLSI 136_ QSLLG 141_ EPNID 146_ SPLNT 151_ HAAEL 156_ WKNPT 161_ AFKKY 166_ LQETY 171_SKQVT
1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit