Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta)
1_MVLLL 6_ CLSCL 11_ IFSCL 16_ TFSWL 21_ KIWGK 26_ MTDSK 31_ PITKS 36_ KSEAN 41_ LIPSQ 46_ EPFPA 51_ SDNSG 56_ ETPQR 61_ NGEGH 66_ TLPKT 71_ PSQAE 76_ PASHK 81_ GPKDA 86_ GRRRN 91_ SLPPS 96_ HQKPP 101_ RNPLS 106_ SSDAA 111_ PSPEL 116_ QANGT 121_ GTQGL 126_ EATDT 131_ NGLSS 136_ SARPQ 141_ GQQAG 146_ SPSKE 151_ DKKQA 156_ NIKRQ 161_ LMTNF 166_ ILGSF 171_ DDYSS 176_ DEDSV 181_ AGSSR 186_ ESTRK 191_ GSRAS 196_ LGALS 201_ LEAYL 206_ TTGEA 211_ ETRVP 216_ TMRPS 221_ MSGLH 226_ LVKRG 231_ REHKK 236_ LDLHR 241_ DFTVA 246_ SPAEF 251_ VTRFG 256_ GDRVI 261_ EKVLI 266_ ANNGI 271_ AAVKC 276_ MRSIR 281_ RWAYE 286_ MFRNE 291_ RAIRF 296_ VVMVT 301_ PEDLK 306_ ANAEY 311_ IKMAD 316_ HYVPV 321_ PGGPN 326_ NNNYA 331_ NVELI 336_ VDIAK 341_ RIPVQ 346_ AVWAG 351_ WGHAS 356_ ENPKL 361_ PELLC 366_ KNGVA 371_ FLGPP 376_ SEAMW 381_ ALGDK 386_ IASTV 391_ VAQTL 396_ QVPTL 401_ PWSGS 406_ GLTVE 411_ WTEDD 416_ LQQGK 421_ RISVP 426_ EDVYD 431_ KGCVK 436_ DVDEG 441_ LEAAE 446_ RIGFP 451_ LMIKA 456_ SEGGG 461_ GKGIR 466_ KAESA 471_ EDFPI 476_ LFRQV 481_ QSEIP 486_ GSPIF 491_ LMKLA 496_ QHARH 501_ LEVQI 506_ LADQY 511_ GNAVS 516_ LFGRD 521_ CSIQR 526_ RHQKI 531_ VEEAP 536_ ATIAP 541_ LAIFE 546_ FMEQC 551_ AIRLA 556_ KTVGY 561_ VSAGT 566_ VEYLY 571_ SQDGS 576_ FHFLE 581_ LNPRL 586_ QVEHP 591_ CTEMI 596_ ADVNL 601_ PAAQL 606_ QIAMG 611_ VPLHR 616_ LKDIR 621_ LLYGE 626_ SPWGV 631_ TPISF 636_ ETPSN 641_ PPLAR 646_ GHVIA 651_ ARITS 656_ ENPDE 661_ GFKPS 666_ SGTVQ 671_ ELNFR 676_ SSKNV 681_ WGYFS 686_ VAATG 691_ GLHEF 696_ ADSQF 701_ GHCFS 706_ WGENR 711_ EEAIS 716_ NMVVA 721_ LKELS 726_ IRGDF 731_ RTTVE 736_ YLINL 741_ LETES 746_ FQNND 751_ IDTGW 756_ LDYLI 761_ AEKVQ 766_ AEKPD 771_ IMLGV 776_ VCGAL 781_ NVADA 786_ MFRTC 791_ MTDFL 796_ HSLER 801_ GQVLP 806_ ADSLL 811_ NLVDV 816_ ELIYG 821_ GVKYI 826_ LKVAR 831_ QSLTM 836_ FVLIM 841_ NGCHI 846_ EIDAH 851_ RLNDG 856_ GLLLS 861_ YNGNS 866_ YTTYM 871_ KEEVD 876_ SYRIT 881_ IGNKT 886_ CVFEK 891_ ENDPT 896_ VLRSP 901_ SAGKL 906_ TQYTV 911_ EDGGH 916_ VEAGS 921_ SYAEM 926_ EVMKM 931_ IMTLN 936_ VQERG 941_ RVKYI 946_ KRPGA 951_ VLEAG 956_ CVVAR 961_ LELDD 966_ PSKVH 971_ PAEPF 976_ TGELP 981_ AQQTL 986_ PILGE 991_ KLHQV 996_ FHSVL 1001_ ENLTN 1006_ VMSGF 1011_ CLPEP 1016_ VFSIK 1021_ LKEWV 1026_ QKLMM 1031_ TLRHP 1036_ SLPLL 1041_ ELQEI 1046_ MTSVA 1051_ GRIPA 1056_ PVEKS 1061_ VRRVM 1066_ AQYAS 1071_ NITSV 1076_ LCQFP 1081_ SQQIA 1086_ TILDC 1091_ HAATL 1096_ QRKAD 1101_ REVFF 1106_ INTQS 1111_ IVQLV 1116_ QRYRS 1121_ GIRGY 1126_ MKTVV 1131_ LDLLR 1136_ RYLRV 1141_ EHHFQ 1146_ QAHYD 1151_ KCVIN 1156_ LREQF 1161_ KPDMS 1166_ QVLDC 1171_ IFSHA 1176_ QVAKK 1181_ NQLVI 1186_ MLIDE 1191_ LCGPD 1196_ PSLSD 1201_ ELISI 1206_ LNELT 1211_ QLSKS 1216_ EHCKV 1221_ ALRAR 1226_ QILIA 1231_ SHLPS 1236_ YELRH 1241_ NQVES 1246_ IFLSA 1251_ IDMYG 1256_ HQFCP 1261_ ENLKK 1266_ LILSE 1271_ TTIFD 1276_ VLPTF 1281_ FYHAN 1286_ KVVCM 1291_ ASLEV 1296_ YVRRG 1301_ YIAYE 1306_ LNSLQ 1311_ HRQLP 1316_ DGTCV 1321_ VEFQF 1326_ MLPSS 1331_ HPNRM 1336_ TVPIS 1341_ ITNPD 1346_ LLRHS 1351_ TELFM 1356_ DSGFS 1361_ PLCQR 1366_ MGAMV 1371_ AFRRF 1376_ EDFTR 1381_ NFDEV 1386_ ISCFA 1391_ NVPKD 1396_ TPLFS 1401_ EARTS 1406_ LYSED 1411_ DCKSL 1416_ REEPI 1421_ HILNV 1426_ SIQCA 1431_ DHLED 1436_ EALVP 1441_ ILRTF 1446_ VQSKK 1451_ NILVD 1456_ YGLRR 1461_ ITFLI 1466_ AQEKE 1471_ FPKFF 1476_ TFRAR 1481_ DEFAE 1486_ DRIYR 1491_ HLEPA 1496_ LAFQL 1501_ ELNRM 1506_ RNFDL 1511_ TAVPC 1516_ ANHKM 1521_ HLYLG 1526_ AAKVK 1531_ EGVEV 1536_ TDHRF 1541_ FIRAI 1546_ IRHSD 1551_ LITKE 1556_ ASFEY 1561_ LQNEG 1566_ ERLLL 1571_ EAMDE 1576_ LEVAF 1581_ NNTSV 1586_ RTDCN 1591_ HIFLN 1596_ FVPTV 1601_ IMDPF 1606_ KIEES 1611_ VRYMV 1616_ MRYGS 1621_ RLWKL 1626_ RVLQA 1631_ EVKIN 1636_ IRQTT 1641_ TGSAV 1646_ PIRLF 1651_ ITNES 1656_ GYYLD 1661_ ISLYK 1666_ EVTDS 1671_ RSGNI 1676_ MFHSF 1681_ GNKQG 1686_ PQHGM 1691_ LINTP 1696_ YVTKD 1701_ LLQAK 1706_ RFQAQ 1711_ TLGTT 1716_ YIYDF 1721_ PEMFR 1726_ QALFK 1731_ LWGSP 1736_ DKYPK 1741_ DILTY 1746_ TELVL 1751_ DSQGQ 1756_ LVEMN 1761_ RLPGG 1766_ NEVGM 1771_ VAFKM 1776_ RFKTQ 1781_ EYPEG 1786_ RDVIV 1791_ IGNDI 1796_ TFRIG 1801_ SFGPG 1806_ EDLLY 1811_ LRASE 1816_ MARAE 1821_ GIPKI 1826_ YVAAN 1831_ SGARI 1836_ GMAEE 1841_ IKHMF 1846_ HVAWV 1851_ DPEDP 1856_ HKGFK 1861_ YLYLT 1866_ PQDYT 1871_ RISSL 1876_ NSVHC 1881_ KHIEE 1886_ GGESR 1891_ YMITD 1896_ IIGKD 1901_ DGLGV 1906_ ENLRG 1911_ SGMIA 1916_ GESSL 1921_ AYEEI 1926_ VTISL 1931_ VTCRA 1936_ IGIGA 1941_ YLVRL 1946_ GQRVI 1951_ QVENS 1956_ HIILT 1961_ GASAL 1966_ NKVLG 1971_ REVYT 1976_ SNNQL 1981_ GGVQI 1986_ MHYNG 1991_ VSHIT 1996_ VPDDF 2001_ EGVYT 2006_ ILEWL 2011_ SYMPK 2016_ DNHSP 2021_ VPIIT 2026_ PTDPI 2031_ DREIE 2036_ FLPSR 2041_ APYDP 2046_ RWMLA 2051_ GRPHP 2056_ TLKGT 2061_ WQSGF 2066_ FDHGS 2071_ FKEIM 2076_ APWAQ 2081_ TVVTG 2086_ RARLG 2091_ GIPVG 2096_ VIAVE 2101_ TRTVE 2106_ VAVPA 2111_ DPANL 2116_ DSEAK 2121_ IIQQA 2126_ GQVWF 2131_ PDSAY 2136_ KTAQA 2141_ VKDFN 2146_ REKLP 2151_ LMIFA 2156_ NWRGF 2161_ SGGMK 2166_ DMYDQ 2171_ VLKFG 2176_ AYIVD 2181_ GLRQY 2186_ KQPIL 2191_ IYIPP 2196_ YAELR 2201_ GGSWV 2206_ VIDAT 2211_ INPLC 2216_ IEMYA 2221_ DKESR 2226_ GGVLE 2231_ PEGTV 2236_ EIKFR 2241_ KKDLI 2246_ KSMRR 2251_ IDPAY 2256_ KKLME 2261_ QLGEP 2266_ DLSDK 2271_ DRKDL 2276_ EGRLK 2281_ AREDL 2286_ LLPIY 2291_ HQVAV 2296_ QFADF 2301_ HDTPG 2306_ RMLEK 2311_ GVISD 2316_ ILEWK 2321_ TARTF 2326_ LYWRL 2331_ RRLLL 2336_ EDQVK 2341_ QEILQ 2346_ ASGEL 2351_ SHVHI 2356_ QSMLR 2361_ RWFVE 2366_ TEGAV 2371_ KAYLW 2376_ DNNQV 2381_ VVQWL 2386_ EQHWQ 2391_ AGDGP 2396_ RSTIR 2401_ ENITY 2406_ LKHDS 2411_ VLKTI 2416_ RGLVE 2421_ ENPEV 2426_ AVDCV 2431_ IYLSQ 2436_ HISPA 2441_ ERAQV 2446_ VHLLS 2451_TMDSP
1: Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity)